Primary Site >> Colorectal Cancer
Gene >> MAPK1
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Ref: Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains. PMID: 8798654 Ref: Estradiol activation of human colon carcinoma-derived Caco-2 cell growth. PMID: 8813150 |
Ref: Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade. PMID: 9191056 Ref: Activated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells. PMID: 9354428 Ref: ErbB kinases and NDF signaling in human prostate cancer cells. PMID: 9400997 |
Ref: Analysis of signaling protein kinases in human colon or colorectal carcinomas. PMID: 9690379 Ref: Signal transduction mechanisms in neurotensin-mediated cellular regulation. PMID: 9706144 Ref: Increased constitutive activity of mitogen-activated protein kinase and renaturable 85 kDa kinase in human-colorectal cancer. PMID: 9823970 |
Ref: Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells. PMID: 10086335 Ref: Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation. PMID: 10214865 Ref: Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation. PMID: 10220499 Ref: Expression and activity of mitogen activated protein kinases in human colorectal carcinoma. PMID: 10323886 Ref: Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells. PMID: 10344756 Ref: Requirement of the MAP kinase cascade for cell cycle progression and differentiation of human intestinal cells. PMID: 10484389 Ref: Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells. PMID: 10519388 Ref: XR3054, structurally related to limonene, is a novel inhibitor of farnesyl protein transferase. PMID: 10533487 Ref: Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. PMID: 10581086 Ref: 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation. PMID: 10585423 |
Ref: Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells. PMID: 10732765 Ref: Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling. PMID: 10748108 Ref: Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. PMID: 10766192 Ref: Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. PMID: 10910078 Ref: [Deregulation of intracellular signal pathways in colorectal carcinoma]. PMID: 10929640 Ref: Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. PMID: 10993892 Ref: Induction of prostaglandin endoperoxide synthase 2 by mitogen-activated protein kinase cascades. PMID: 11085935 |
Ref: Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis. PMID: 11159738 Ref: Inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and induction of apoptosis by sulindac metabolites. PMID: 11245463 Ref: EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells. PMID: 11259102 Ref: Endothelial cell apoptosis is inhibited by a soluble factor secreted by human colon cancer cells. PMID: 11279602 Ref: Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancer. PMID: 11319881 Ref: Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells. PMID: 11322385 Ref: Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation. PMID: 11375905 Ref: Alterations of MAPK activities associated with intestinal cell differentiation. PMID: 11394874 Ref: Transendothelial migration of colon carcinoma cells requires expression of E-selectin by endothelial cells and activation of stress-activated protein kinase-2 (SAPK2/p38) in the tumor cells. PMID: 11448946 Ref: The protrusive phase and full development of integrin-dependent adhesions in colon epithelial cells require FAK- and ERK-mediated actin spike formation: deregulation in cancer cells. PMID: 11494115 Ref: Butyrate and propionate downregulate ERK phosphorylation in HT-29 colon carcinoma cells prior to differentiation. PMID: 11535873 Ref: Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer. PMID: 11605075 Ref: Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells. PMID: 11781819 Ref: Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway. PMID: 11806247 Ref: Beta-carotene inhibits growth of human colon carcinoma cells in vitro by induction of apoptosis. PMID: 11843179 Ref: Neurotensin-and EGF-induced metabolic activation of colon carcinoma cells is diminished by dietary flavonoid cyanidin but not by its glycosides. PMID: 12094622 Ref: Inhibition of Kirsten-ras expression in human colorectal cancer using rationally selected Kirsten-ras antisense oligonucleotides. PMID: 12467236 |
Ref: Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells. PMID: 11791178 Ref: Role of redox status on the activation of mitogen-activated protein kinase cascades by NSAIDs. PMID: 11841790 Ref: Direct integrin alphavbeta6-ERK binding: implications for tumour growth. PMID: 11857080 Ref: Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. PMID: 11875501 Ref: Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells. PMID: 11888673 Ref: Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. PMID: 11891209 Ref: Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line. PMID: 11910351 Ref: Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. PMID: 11986622 Ref: Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells. PMID: 11989975 Ref: The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. PMID: 11992399 Ref: Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the beta6 integrin subunit. PMID: 11992542 Ref: Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B. PMID: 12077118 Ref: Integrin alpha(v)beta6-associated ERK2 mediates MMP-9 secretion in colon cancer cells. PMID: 12177807 Ref: Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells. PMID: 12203364 Ref: Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells. PMID: 12220644 Ref: Red wine polyphenols inhibit the growth of colon carcinoma cells and modulate the activation pattern of mitogen-activated protein kinases. PMID: 12221251 Ref: Benzo(a)pyrene activates extracellular signal-related and p38 mitogen-activated protein kinases in HT29 colon adenocarcinoma cells: involvement in NAD(P)H:quinone reductase activity and cell proliferation. PMID: 12383707 Ref: Therapeutics targeting signal transduction for patients with colorectal carcinoma. PMID: 12421735 |
Ref: Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity. PMID: 12475986 Ref: Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. PMID: 12566304 Ref: Regulation of leukotriene-dependent induction of cyclooxygenase-2 and Bcl-2. PMID: 12604350 Ref: Opposing effects of butyrate and bile acids on apoptosis of human colon adenoma cells: differential activation of PKC and MAP kinases. PMID: 12618885 Ref: Proteomic profiling of proteins associated with urokinase plasminogen activator receptor in a colon cancer cell line using an antisense approach. PMID: 12627382 Ref: Integrin alpha2 and extracellular signal-regulated kinase are functionally linked in highly malignant autocrine transforming growth factor-alpha-driven colon cancer cells. PMID: 12657625 Ref: Alpha2beta1-integrin signaling by itself controls G1/S transition in a human adenocarcinoma cell line (Caco-2): implication of NADPH oxidase-dependent production of ROS. PMID: 12681287 Ref: Platelet-activating factor activates mitogen-activated protein kinases, inhibits proliferation, induces differentiation and suppresses the malignant phenotype of human colon carcinoma cells. PMID: 12687020 Ref: Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. PMID: 12727858 Ref: Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells. PMID: 12748850 Ref: Raf proteins and cancer: B-Raf is identified as a mutational target. PMID: 12781369 Ref: Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. PMID: 12802055 Ref: The ERK pathway involves positive and negative regulations of HT-29 colorectal cancer cell growth by extracellular zinc. PMID: 12816758 Ref: The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. PMID: 12819185 Ref: Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells. PMID: 12865932 Ref: Absence of adhesion triggers differential FAK and SAPKp38 signals in SW620 human colon cancer cells that may inhibit adhesiveness and lead to cell death. PMID: 12876384 Ref: Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. PMID: 12888657 Ref: ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. PMID: 12892714 Ref: Diallyl disulfide induces ERK phosphorylation and alters gene expression profiles in human colon tumor cells. PMID: 12949385 Ref: Inhibition of angiogenesis by NSAIDs: molecular mechanisms and clinical implications. PMID: 13679997 Ref: MAP kinase-mediated proliferation of DLD-1 carcinoma by the stimulation of protease-activated receptor 2. PMID: 14511767 Ref: Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. PMID: 14556662 Ref: The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines. PMID: 14608117 Ref: Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. PMID: 14623871 Ref: Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells. PMID: 14625389 Ref: Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors. PMID: 14678966 |
Ref: Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling. PMID: 14699482 Ref: Ursodeoxycholic acid (UDCA) can inhibit deoxycholic acid (DCA)-induced apoptosis via modulation of EGFR/Raf-1/ERK signaling in human colon cancer cells. PMID: 14747693 Ref: Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway. PMID: 14981539 Ref: In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. PMID: 14991899 Ref: Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK. PMID: 15078890 Ref: Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK. PMID: 15122344 Ref: Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation. PMID: 15123663 Ref: Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis. PMID: 15161648 Ref: 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells. PMID: 15165036 Ref: Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway. PMID: 15177310 Ref: COX-2 inhibitors and other nonsteroidal anti-inflammatory drugs in genitourinary cancer. PMID: 15179622 Ref: C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression. PMID: 15205382 Ref: Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin. PMID: 15247276 Ref: Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells. PMID: 15256484 Ref: Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells. PMID: 15304500 Ref: n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. PMID: 15358633 Ref: p38 MAPK signaling pathway is involved in butyrate-induced vitamin D receptor expression. PMID: 15504345 Ref: EGF-receptor related protein causes cell cycle arrest and induces apoptosis of colon cancer cells in vitro and in vivo. PMID: 15517892 Ref: Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation. PMID: 15542810 Ref: Extracellular pressure stimulates colon cancer cell proliferation via a mechanism requiring PKC and tyrosine kinase signals. PMID: 15548175 Ref: Inhibition of extracellular-signal regulated kinases 1/2 is required for apoptosis of human colon cancer cells in vitro by sulindac metabolites. PMID: 15548677 Ref: [Complex forms of immune insufficiency to some cytokines (TNF-alpha, interferons) in colorectal cancers as exemplified by the COLO 205 cell line. Mechanism of resistance with special reference to signaling proteins and cytokines]. PMID: 15577750 Ref: p21Cip/WAF1 activation is an important factor for the ERK pathway dependent anti-proliferation of colorectal cancer cells. PMID: 15665589 |
Ref: Selenomethionine induces sustained ERK phosphorylation leading to cell-cycle arrest in human colon cancer cells. PMID: 15513932 Ref: Quinoxaline 1,4-dioxides induce G2/M cell cycle arrest and apoptosis in human colon cancer cells. PMID: 15538569 Ref: The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. PMID: 15590642 Ref: Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells. PMID: 15618237 Ref: Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2-mediated proliferation of colon cancer cell. PMID: 15655297 Ref: Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells. PMID: 15655348 Ref: Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production. PMID: 15655524 Ref: The macrophage inhibitory cytokine integrates AKT/PKB and MAP kinase signaling pathways in breast cancer cells. PMID: 15677629 Ref: Mutations of the BRAF gene in ulcerative colitis-related colorectal carcinoma. PMID: 15704157 Ref: H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent. PMID: 15713896 Ref: Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells. PMID: 15713899 Ref: BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms. PMID: 15729718 Ref: Combined inhibition of extracellular signal-regulated kinases and HSP90 sensitizes human colon carcinoma cells to ionizing radiation. PMID: 15735687 Ref: Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. PMID: 15735759 Ref: Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor signaling. PMID: 15746213 Ref: (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells. PMID: 15860507 Ref: Supra-additive growth inhibition by a celecoxib analogue and carboxyamido-triazole is primarily mediated through apoptosis. PMID: 15867384 Ref: Interactions between human colon carcinoma cells, fibroblasts and monocytic cells in coculture--regulation of cathepsin B expression and invasiveness. PMID: 15896466 Ref: In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models. PMID: 15897558 Ref: Ornithine decarboxylase, mitogen-activated protein kinase and matrix metalloproteinase-2 expressions in human colon tumors. PMID: 15918191 Ref: Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. PMID: 15922743 Ref: Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells. PMID: 15930183 Ref: The SRC-induced mesenchymal state in late-stage colon cancer cells. PMID: 15942195 Ref: Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells. PMID: 15975962 Ref: Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. PMID: 16024629 Ref: Leptin, insulin-like growth factor-1, and insulin-like growth factor-2 are mitogens in ApcMin/+ but not Apc+/+ colonic epithelial cell lines. PMID: 16030096 Ref: Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. PMID: 16052481 Ref: 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal tra PMID: 16077033 Ref: CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation. PMID: 16125170 Ref: Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid decreases ErbB3 expression in HT-29 human colon cancer cells. PMID: 16127743 Ref: Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells. PMID: 16142585 Ref: Gastrin suppresses growth of CCK2 receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo. PMID: 16143134 Ref: Induction of apoptotic cell death by 2'-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells. PMID: 16143316 Ref: Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signalling in the regulation of growth and differentiation in colon carcinoma. PMID: 16278666 Ref: Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. PMID: 16288056 Ref: Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased Raf-1 ubiquitin-dependent degradation. PMID: 16294035 Ref: Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen activated protein kinase cell signaling. PMID: 16327498 Ref: EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells. PMID: 16416603 |
Ref: Glycine-extended gastrin stimulates proliferation and inhibits apoptosis in colon cancer cells via cyclo-oxygenase-independent pathways. PMID: 16169610 Ref: Molecular signaling cascade in DNA bisintercalator, echinomycin-induced apoptosis of HT-29 cells: evidence of the apoptotic process via activation of the cytochrome c-ERK-caspase-3 pathway. PMID: 16214385 Ref: Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells. PMID: 16215992 Ref: Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling. PMID: 16241905 Ref: Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase. PMID: 16278684 Ref: Alpha-chaconine, a potato glycoalkaloid, induces apoptosis of HT-29 human colon cancer cells through caspase-3 activation and inhibition of ERK 1/2 phosphorylation. PMID: 16387404 Ref: Mitogen-activated protein kinase signaling is activated in prostate tumors but not mediated by B-RAF mutations. PMID: 16413100 Ref: Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway. PMID: 16461767 Ref: Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells. PMID: 16475687 Ref: APC inhibits ERK pathway activation and cellular proliferation induced by RAS. PMID: 16478791 Ref: RRR-alpha-tocopherol succinate down-regulates oncogenic Ras signaling. PMID: 16505104 Ref: Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells. PMID: 16529829 Ref: Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis. PMID: 16575407 Ref: Effects of extracts from two Native American plants on proliferation of human breast and colon cancer cell lines in vitro. PMID: 16596206 Ref: Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatase(s) and reducing ERK1/2 activity via a novel pathway. PMID: 16611738 Ref: The tyrosine kinase inhibitor AG490 inhibits growth of cancer cells and activates ERK in LS174T and HT-29 cells. PMID: 16619510 Ref: Requirement of the enzymatic and signaling activities of plasmin for phorbol-ester-induced scattering of colon cancer cells. PMID: 16631161 Ref: Hepatocyte growth factor installs a survival platform for colorectal cancer cell invasive growth and overcomes p38 MAPK-mediated apoptosis. PMID: 16677802 Ref: Arachidonic acid-induced gene expression in colon cancer cells. PMID: 16704987 Ref: Regulation of transendothelial migration of colon cancer cells by E-selectin-mediated activation of p38 and ERK MAP kinases. PMID: 16715142 Ref: Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner. PMID: 16728583 Ref: A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. PMID: 16731769 Ref: [Role of calcium signal in apoptosis and protective mechanism of colon cancer cell line SW480 in response to 5-aminolevulinic acid-photodynamic therapy]. PMID: 16764761 Ref: Stress-induced phosphorylation of caveolin-1 and p38, and down-regulation of EGFr and ERK by the dietary lectin jacalin in two human carcinoma cell lines. PMID: 16817319 Ref: Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. PMID: 16959882 Ref: Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells. PMID: 16964382 Ref: Death receptor-3, a new E-Selectin counter-receptor that confers migration and survival advantages to colon carcinoma cells by triggering p38 and ERK MAPK activation. PMID: 16982754 Ref: Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer. PMID: 17007015 Ref: Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells. PMID: 17047069 Ref: Phytoestrogens regulate transcription and translation of vitamin D receptor in colon cancer cells. PMID: 17088408 Ref: Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells. PMID: 17113582 |
Ref: MAGI-3 regulates LPA-induced activation of Erk and RhoA. PMID: 16904289 Ref: Conjugated linoleic acid inhibits Caco-2 cell growth via ERK-MAPK signaling pathway. PMID: 16963252 Ref: L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. PMID: 17030349 Ref: Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells. PMID: 17130837 Ref: Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations. PMID: 17149612 Ref: Anti-EGFR and ErbB-2 antibodies attenuate cyclooxygenase-2 expression and cooperatively inhibit survival of human colon cancer cells. PMID: 17189670 Ref: Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer. PMID: 17220595 Ref: A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo. PMID: 17234777 Ref: Involvement of Ras/Raf-1/ERK actions in the magnolol-induced upregulation of p21 and cell-cycle arrest in colon cancer cells. PMID: 17295239 Ref: Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells. PMID: 17307743 Ref: BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK. PMID: 17317101 Ref: Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation. PMID: 17329004 Ref: The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T. PMID: 17374366 Ref: Profiling of selenomethionine responsive genes in colon cancer by microarray analysis. PMID: 17374985 Ref: XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer. PMID: 17385215 Ref: Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. PMID: 17409437 Ref: Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease. PMID: 17449633 Ref: Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. PMID: 17478078 Ref: Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells. PMID: 17488804 Ref: ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. PMID: 17513607 Ref: Promotion of cancer cell migration: an insulin-like growth factor (IGF)-independent action of IGF-binding protein-6. PMID: 17519236 Ref: Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways. PMID: 17531111 Ref: Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad. PMID: 17544220 Ref: A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model. PMID: 17574271 Ref: The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. PMID: 17583570 Ref: RAGE activation by S100P in colon cancer stimulates growth, migration, and cell signaling pathways. PMID: 17587138 Ref: Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein. PMID: 17620438 Ref: Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells. PMID: 17631144 Ref: The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. PMID: 17631291 Ref: Bone morphogenetic protein-4 inhibits heat-induced apoptosis by modulating MAPK pathways in human colon cancer HCT116 cells. PMID: 17640799 Ref: HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts. PMID: 17640979 Ref: [Effects of extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activation on proliferation and cell cycle associated genes in human colon cancer cells]. PMID: 17650425 Ref: Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. PMID: 17667937 Ref: Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. PMID: 17671177 Ref: A cholesterol-independent membrane microdomain serves as a functional counter-receptor for E-selectin at the Colo201 cell surface and initiates signalling on E-selectin binding. PMID: 17684030 Ref: Keratinocyte growth factor-transfection-stimulated adhesion of colorectal cancer cells to extracellular matrices. PMID: 17706640 Ref: Thermal sensitization through ROS modulation: a strategy to improve the efficacy of hyperthermic intraperitoneal chemotherapy. PMID: 17723891 Ref: 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase. PMID: 17880056 Ref: Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation. PMID: 17909036 Ref: The CCK-2/gastrin splice variant receptor retaining intron 4 transactivates the COX-2 promoter in vitro. PMID: 17936921 Ref: [Regulation of promatrilysin expression by tissue factor/actived coagulation factor VII complex in LoVo colon cancer cell line]. PMID: 17940558 Ref: Bilirubin inhibits tumor cell growth via activation of ERK. PMID: 18073533 Ref: Proteasome inhibition potentiates the cytotoxic effects of hyperthermia in HT-29 colon cancer cells through inhibition of heat shock protein 27. PMID: 18337621 |
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PMID: 27167191 Ref: In Hyperthermia Increased ERK and WNT Signaling Suppress Colorectal Cancer Cell Growth. PMID: 27187477 Ref: Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2 Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells. PMID: 27192488 Ref: SH3GL1 inhibition reverses multidrug resistance in colorectal cancer cells by downregulation of MDR1/P-glycoprotein via EGFR/ERK/AP-1 pathway. PMID: 27220321 Ref: Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects. PMID: 27224059 Ref: Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule. PMID: 27224913 Ref: Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs. PMID: 27259276 Ref: Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice. PMID: 27270323 Ref: Blockage of Autophagy Rescues the Dual PI3K/mTOR Inhibitor BEZ235-induced Growth Inhibition of Colorectal Cancer Cells. PMID: 27294206 Ref: Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer. PMID: 27304964 Ref: Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer. PMID: 27312529 Ref: Inhibition of the NF-kappaB pathway by nafamostat mesilate suppresses colorectal cancer growth and metastasis. PMID: 27322737 Ref: Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer. PMID: 27323826 Ref: Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer. PMID: 27323830 Ref: Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation. PMID: 27347133 Ref: BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells. PMID: 27351224 Ref: Enhanced TLR4 Expression on Colon Cancer Cells After Chemotherapy Promotes Cell Survival and Epithelial-Mesenchymal Transition Through Phosphorylation of GSK3beta. PMID: 27354597 Ref: CCR4 promotes metastasis via ERK/NF-kappaB/MMP13 pathway and acts downstream of TNF-alpha in colorectal cancer. PMID: 27356745 Ref: Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation. PMID: 27369075 Ref: Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922. PMID: 27391062 Ref: Expression of the chemokine CXCL14 and cetuximab-dependent tumour suppression in head and neck squamous cell carcinoma. PMID: 27399917 Ref: Flagellin Induces beta-Defensin 2 in Human Colonic Ex vivo Infection with Enterohemorrhagic Escherichia coli. PMID: 27446815 Ref: Sur8 mediates tumorigenesis and metastasis in colorectal cancer. PMID: 27469030 Ref: Anticancer Activity of Buttermilk Against SW480 Colon Cancer Cells is Associated with Caspase-Independent Cell Death and Attenuation of Wnt, Akt, and ERK Signaling. PMID: 27472445 Ref: Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. PMID: 27496966 Ref: Decreased expression of LncRNA SLC25A25-AS1 promotes proliferation, chemoresistance, and EMT in colorectal cancer cells. PMID: 27553025 Ref: All-Trans Retinoic Acid Inhibits Human Colorectal Cancer Cells RKO Migration via Downregulating Myosin Light Chain Kinase Expression through MAPK Signaling Pathway. PMID: 27564600 Ref: Role of neutral ceramidase in colon cancer. PMID: 27609772 Ref: Current understanding concerning intestinal stem cells. PMID: 27610020 Ref: Gefitinib enhances human colon cancer cells to TRAIL-induced apoptosis of via autophagy- and JNK-mediated death receptors upregulation. PMID: 27629794 Ref: Downregulation of RLIP76 is associated with vincristine resistance in human colorectal cancer HCT-8/VCR cells. PMID: 27633085 Ref: Glucose-regulated protein 78 contributes to the proliferation and tumorigenesis of human colorectal carcinoma via AKT and ERK pathways. PMID: 27634156 Ref: STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways. PMID: 27662663 Ref: Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells. PMID: 27698814 Ref: Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model. PMID: 27729020 Ref: Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks. PMID: 27729552 Ref: Claudin-1 promotes TNF-alpha-induced epithelial-mesenchymal transition and migration in colorectal adenocarcinoma cells. PMID: 27742576 Ref: Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer. PMID: 27765849 Ref: Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into beta-arrestin-dependent ERK signaling. PMID: 27835898 Ref: Enhanced anti-tumour activity of the combination of the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037. PMID: 27837257 Ref: CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer. PMID: 27942222 Ref: miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer. PMID: 28105166 Ref: Akt-dependent activation of Erk by cyclin D1b contributes to cell invasiveness and tumorigenicity. PMID: 28105192 |
Ref: Camptothecin promotes the production of nitric oxide that triggers subsequent S-nitrosoproteome-mediated signaling cascades in endothelial cells. PMID: 26239883 Ref: Inhibition of NF-kappaB and metastasis in irinotecan (CPT-11)-resistant LoVo colon cancer cells by thymoquinone via JNK and p38. PMID: 27060453 Ref: Suppression of Spleen Tyrosine Kinase (Syk) by Histone Deacetylation Promotes, Whereas BAY61-3606, a Synthetic Syk Inhibitor Abrogates Colonocyte Apoptosis by ERK Activation. PMID: 27293079 Ref: FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation. PMID: 27399335 Ref: Smyd3-associated regulatory pathways in cancer. PMID: 27554136 Ref: Inhibition of RAF1 kinase activity restores apicobasal polarity and impairs tumour growth in human colorectal cancer. PMID: 27670374 Ref: The MAPK Pathway Regulates Intrinsic Resistance to BET Inhibitors in Colorectal Cancer. PMID: 27678457 Ref: Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice. PMID: 27845068 Ref: Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression. PMID: 27859949 Ref: SN38 increases IL-8 expression through the MAPK pathways in HCT8 cells. PMID: 27878250 Ref: FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway. PMID: 27926503 Ref: Fibroblast growth factor 18 promotes proliferation and migration of H460 cells via the ERK and p38 signaling pathways. PMID: 27959447 Ref: LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer. PMID: 27999210 Ref: Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells. PMID: 28008134 Ref: Taspine derivative 12k suppressed A549 cell migration through the Wnt/beta-catenin and EphrinB2 signaling pathway. PMID: 28049091 Ref: SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer. PMID: 28088387 Ref: Knockdown of NIK and IKKbeta-Binding Protein (NIBP) Reduces Colorectal Cancer Metastasis through Down-Regulation of the Canonical NF-kappaBeta Signaling Pathway and Suppression of MAPK Signaling Mediated through ERK and JNK. PMID: 28125661 Ref: Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo. PMID: 28165459 Ref: Biased Signaling by Agonists of Protease Activated Receptor 2. PMID: 28169521 Ref: Targeting TRK family proteins in cancer. PMID: 28174090 Ref: microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways. 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PMID: 28341244 Ref: NUBPL, a novel metastasis-related gene, promotes colorectal carcinoma cell motility by inducing epithelial-mesenchymal transition. PMID: 28346728 Ref: Assessment of Olea europaea L. fruit extracts: Phytochemical characterization and anticancer pathway investigation. PMID: 28360012 Ref: Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance. PMID: 28368067 Ref: TGFbeta engages MEK/ERK to differentially regulate benign and malignant pancreas cell function. PMID: 28368414 Ref: [Inhibitory effect of apatinib on HCT-116 cells and its mechanism]. PMID: 28377354 Ref: RSK activation via ERK modulates human colon cancer cells response to PTHrP. PMID: 28385776 Ref: Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells. PMID: 28386381 Ref: Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer. PMID: 28412748 Ref: A crosstalk between muscarinic and CRF2 receptors regulates cellular adhesion properties of human colon cancer cells. PMID: 28432022 Ref: Rational design of non-resistant targeted cancer therapies. PMID: 28436422 Ref: Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis. PMID: 28455144 Ref: Vitex rotundifolia Fruit Extract Induces Apoptosis Through the Downregulation of ATF3-Mediated Bcl-2 Expression in Human Colorectal Cancer Cells. PMID: 28468511 Ref: Antagonistic Interactions between Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Retinoic Acid Receptor Signaling in Colorectal Cancer Cells. PMID: 28483913 Ref: The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia. PMID: 28486050 Ref: Panitumumab interaction with TAS-102 leads to combinational anticancer effects via blocking of EGFR-mediated tumor response to trifluridine. PMID: 28486761 Ref: Fas signaling induces stemness properties in colorectal cancer by regulation of Bmi1. PMID: 28543447 Ref: Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line. PMID: 28571588 Ref: Continuous or Transient High Level of Glucose Exposure Differentially Increases Coronary Artery Endothelial Cell Proliferation and Human Colon Cancer Cell Proliferation. PMID: 28580314 Ref: Anti-fibrogenic effect of PPAR-gamma agonists in human intestinal myofibroblasts. PMID: 28592228 Ref: TRIB1 promotes colorectal cancer cell migration and invasion through activation MMP-2 via FAK/Src and ERK pathways. PMID: 28624785 Ref: Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner. PMID: 28630428 Ref: Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies. PMID: 28640835 Ref: Correction: CCR4 promotes metastasis via ERK/NF-kappaB/MMP13 pathway and acts downstream of TNF-alpha in colorectal cancer. PMID: 28645139 Ref: Clinical responses to ERK inhibition in BRAF(V600E)-mutant colorectal cancer predicted using a computational model. PMID: 28649441 Ref: BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity. PMID: 28655712 Ref: Effect of nonylphenol on the regulation of cell growth in colorectal cancer cells. PMID: 28656208 Ref: Indole phytoalexin derivatives induce mitochondrial-mediated apoptosis in human colorectal carcinoma cells. PMID: 28706417 Ref: Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-kappaB Signaling. PMID: 28726723 Ref: Long non-coding RNA XIST functions as an oncogene in human colorectal cancer by targeting miR-132-3p. PMID: 28730777 Ref: miR-141 Inhibits Proliferation and Migration of Colorectal Cancer SW480 Cells. PMID: 28739727 Ref: A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution. PMID: 28746882 Ref: Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth. PMID: 28759012 Ref: Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11. PMID: 28781653 Ref: Antitumor activity of beta-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways. PMID: 28782499 Ref: HspB5 correlates with poor prognosis in colorectal cancer and prompts epithelial-mesenchymal transition through ERK signaling. PMID: 28796798 Ref: Dual inhibition of MET and SRC kinase activity as a combined targeting strategy for colon cancer. PMID: 28810597 Ref: An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer. PMID: 28811578 Ref: Leuconostoc mesenteroides-derived anticancer pharmaceuticals hinder inflammation and cell survival in colon cancer cells by modulating NF-kappaB/AKT/PTEN/MAPK pathways. PMID: 28821160 Ref: Syndecan-2 cytoplasmic domain up-regulates matrix metalloproteinase-7 expression via the protein kinase Cgamma-mediated FAK/ERK signaling pathway in colon cancer. PMID: 28821612 Ref: TIF1beta is phosphorylated at serine 473 in colorectal tumor cells through p38 mitogen-activated protein kinase as an oxidative defense mechanism. PMID: 28864417 Ref: Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells. PMID: 28870200 Ref: Erratum: Clinical responses to ERK inhibition in BRAF(V600E)-mutant colorectal cancer predicted using a computational model. PMID: 28879057 Ref: PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transition. PMID: 28915620 Ref: In vitro anticancer activity of new gold(III) porphyrin complexes in colon cancer cells. PMID: 28923355 Ref: Targeting progastrin enhances radiosensitization of colorectal cancer cells. PMID: 28938581 Ref: Sulforaphane induces p53deficient SW480 cell apoptosis via the ROSMAPK signaling pathway. PMID: 28944886 Ref: Ca(2+)/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways. PMID: 28970726 Ref: SUMOylation of IQGAP1 promotes the development of colorectal cancer. PMID: 28987385 Ref: Downregulation of ZNF278 arrests the cell cycle and decreases the proliferation of colorectal cancer cells via inhibition of the ERK/MAPK pathway. PMID: 29039562 Ref: MicroRNA337 inhibits colorectal cancer progression by directly targeting KRAS and suppressing the AKT and ERK pathways. PMID: 29048669 Ref: Functional consequence of the p53 codon 72 polymorphism in colorectal cancer. PMID: 29100333 Ref: Coix lacryma-jobi var. ma-yuen Stapf sprout extract has anti-metastatic activity in colon cancer cells in vitro. PMID: 29110726 Ref: miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1. PMID: 29118671 Ref: Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner. PMID: 29233468 Ref: Netrin-1 Prevents Rat Primary Cortical Neurons from Apoptosis via the DCC/ERK Pathway. PMID: 29321724 Ref: Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells. PMID: 29340103 Ref: Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways. PMID: 29344237 Ref: Hedyotis diffusa willd extract suppresses colorectal cancer growth through multiple cellular pathways. PMID: 29344262 |
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PMID: 28933585 Ref: Role of JMJD2B in colon cancer cell survival under glucose-deprived conditions and the underlying mechanisms. PMID: 28945223 Ref: Oleanolic Acid Inhibits Colorectal Cancer Angiogenesis by Blocking the VEGFR2 Signaling Pathway. PMID: 29065844 Ref: HOXA3 promotes tumor growth of human colon cancer through activating EGFR/Ras/Raf/MEK/ERK signaling pathway. PMID: 29073728 Ref: MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells. PMID: 29084209 Ref: Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer. PMID: 29095547 Ref: MAPK inhibitors induce serine peptidase inhibitor Kazal type 1 (SPINK1) secretion in BRAF V600E-mutant colorectal adenocarcinoma. PMID: 29193645 Ref: Fibroblast activation protein-alpha in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways. PMID: 29207091 Ref: Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer. PMID: 29233910 Ref: Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells. PMID: 29255136 Ref: Vitex rotundifolia Fruit Suppresses the Proliferation of Human Colorectal Cancer Cells through Down-regulation of Cyclin D1 and CDK4 via Proteasomal-Dependent Degradation and Transcriptional Inhibition. PMID: 29298515 Ref: Effect of long non-coding RNA Gas5 on proliferation, migration, invasion and apoptosis of colorectal cancer HT-29 cell line. PMID: 29308053 Ref: Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. PMID: 29328495 Ref: Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway. PMID: 29344654 Ref: Targeting M3 Muscarinic Receptors for Colon Cancer Therapy. PMID: 29357811 Ref: Synthesis, anticancer assessment on human breast, liver and colon carcinoma cell lines and molecular modeling study using novel pyrazolo[4,3-c]pyridine derivatives. PMID: 29367077 Ref: DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis. PMID: 29379130 Ref: p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells. PMID: 29402939 Ref: Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in BRAF(V600E) Colorectal Cancer. PMID: 29431697 Ref: Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling. PMID: 29440765 Ref: Interaction of the Wnt/beta-catenin and RAS-ERK pathways involving co-stabilization of both beta-catenin and RAS plays important roles in the colorectal tumorigenesis. PMID: 29449169 Ref: Construction of key signal regulatory network in metastatic colorectal cancer. PMID: 29464057 Ref: TNF-alpha promotes colon cancer cell migration and invasion by upregulating TROP-2. PMID: 29467899 Ref: TGFBR1*6A is a potential modifier of migration and invasion in colorectal cancer cells. PMID: 29467907 Ref: Impairment of K-Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR-143. PMID: 29498789 Ref: Indoleamine 2,3-dioxygenase expression regulates the survival and proliferation of Fusobacterium nucleatum in THP-1-derived macrophages. PMID: 29500439 Ref: Expressions of IGF-1, ERK, GLUT4, IRS-1 in metabolic syndrome complicated with colorectal cancer and their associations with the clinical characteristics of CRC. PMID: 29504525 Ref: Phosphorylation of p70 Ribosomal Protein S6 Kinase beta-1 is an Independent Prognostic Parameter in Metastatic Colorectal Cancer. PMID: 29526493 Ref: Inhibition of microRNA-21-3p suppresses proliferation as well as invasion and induces apoptosis by targeting RNA-binding protein with multiple splicing through Smad4/extra cellular signal-regulated protein kinase signalling pathway in human colorectal can PMID: 29542167 Ref: Expression of factors and key components associated with the PI3K signaling pathway in colon cancer. PMID: 29552187 Ref: Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells. PMID: 29568348 Ref: Advances on the BRAF Front in Colorectal Cancer. PMID: 29610287 Ref: Propofol Disrupts Aerobic Glycolysis in Colorectal Cancer Cells via Inactivation of the NMDAR-CAMKII-ERK Pathway. PMID: 29614493 Ref: p38 inhibitor inhibits the apoptosis of cowanin-treated human colorectal adenocarcinoma cells. PMID: 29620273 Ref: Gambogic Acid Efficiently Kills Stem-Like Colorectal Cancer Cells by Upregulating ZFP36 Expression. 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PMID: 29748135 Ref: LIFR promotes tumor angiogenesis by up-regulating IL-8 levels in colorectal cancer. PMID: 29751081 Ref: Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A. PMID: 29761838 Ref: Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells. PMID: 29794421 Ref: shRNAinduced knockdown of the SPERT gene inhibits proliferation and promotes apoptosis of human colorectal cancer RKO cells. PMID: 29845259 Ref: AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells. PMID: 29846015 Ref: NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway. PMID: 29857489 Ref: Dioscorea bulbifera induced apoptosis through inhibition of ERK 1/2 and activation of JNK signaling pathways in HCT116 human colorectal carcinoma cells. PMID: 29860114 Ref: Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a beta1-integrin-FAK-YAP1/TAZ signaling pathway. PMID: 29872721 Ref: Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1alpha axis. PMID: 29884183 Ref: FOXD1 predicts prognosis of colorectal cancer patients and promotes colorectal cancer progression via the ERK 1/2 pathway. PMID: 29887965 Ref: Fibroblast growth factor 18 promotes the growth, migration and invasion of MDAMB231 cells. PMID: 29901199 Ref: CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin. PMID: 29921293 Ref: EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis. PMID: 29923200 Ref: Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells. PMID: 29928348 Ref: Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer. PMID: 29980571 Ref: ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer. PMID: 29988110 Ref: Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP. PMID: 30009852 Ref: Combination of BEZ235 and Metformin Has Synergistic Effect on Cell Viability in Colorectal Cancer Cells. PMID: 30023463 Ref: The Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis in Intestinal Epithelial Cells Regulates Intestinal Barrier Function During Intestinal Epithelial Cells-CD4+T-Cell Interactions. PMID: 30045015 Ref: Restoration of miR-152 expression suppresses cell proliferation, survival, and migration through inhibition of AKT-ERK pathway in colorectal cancer. PMID: 30076720 Ref: Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo. PMID: 30097113 Ref: Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment. PMID: 30103709 Ref: Molecular subtypes of colorectal cancer in pre-clinical models show differential response to targeted therapies: Treatment implications beyond KRAS mutations. PMID: 30118499 Ref: miR-372 and miR-373 enhance the stemness of colorectal cancer cells by repressing differentiation signaling pathways. PMID: 30171794 Ref: Targeting BRAF Mutations in High-Grade Neuroendocrine Carcinoma of the Colon. PMID: 30181415 Ref: NCOA4-RET fusion in colorectal cancer: Therapeutic challenge using patient-derived tumor cell lines. PMID: 30210625 Ref: FABP7 promotes cell proliferation and survival in colon cancer through MEK/ERK signaling pathway. PMID: 30218856 Ref: HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways. PMID: 30231922 Ref: Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer. PMID: 30234098 Ref: PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/beta-catenin signaling pathway. PMID: 30243096 Ref: HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer. PMID: 30258050 Ref: Suppression of angiogenesis and tumor growth by recombinant T4 phages displaying extracellular domain of vascular endothelial growth factor receptor 2. PMID: 30259141 Ref: STK899704 inhibits stemness of cancer stem cells and migration via the FAK-MEK-ERK pathway in HT29 cells. PMID: 30269740 Ref: MicroRNA-145 regulates the proliferation, migration and invasion of human primary colon adenocarcinoma cells by targeting MAPK1. PMID: 30272312 Ref: miR124 inhibits cell growth through targeting IQGAP1 in colorectal cancer. PMID: 30272357 Ref: miR-3148 Is a Novel Onco-microRNA that Potentiates Tumor Growth In Vivo. PMID: 30275189 Ref: Incremental Elevations in TNFalpha and IL6 in the Human Colon and Procancerous Changes in the Mucosal Transcriptome Accompany Adiposity. PMID: 30291114 Ref: Antisense Oligonucleotides against miR-21 Inhibit the Growth and Metastasis of Colorectal Carcinoma via the DUSP8 Pathway. PMID: 30317164 Ref: Systematic identification of celastrol-binding proteins reveals that Shoc2 is inhibited by celastrol. PMID: 30333251 Ref: alpha-Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-kappaB Signaling in Colon Cancer Cells. PMID: 30363706 Ref: PEA15 promotes liver metastasis of colorectal cancer by upregulating the ERK/MAPK signaling pathway. PMID: 30365128 Ref: Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1. PMID: 30382763 Ref: The small organic molecule C19 binds and strengthens the KRAS4b-PDEdelta complex and inhibits growth of colorectal cancer cells in vitro and in vivo. PMID: 30382908 |