Primary Site >> Colorectal Cancer
Gene >> MAP2K2
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Ref: Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. PMID: 12149254 |
Ref: EGF receptor-related protein (ERRP) inhibits invasion of colon cancer cells and tubule formation by endothelial cells in vitro. PMID: 16619503 |
Ref: Rapid identification of somatic mutations in colorectal and breast cancer tissues using mismatch repair detection (MRD). PMID: 18186519 Ref: Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells. PMID: 18533112 Ref: Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets. PMID: 18940803 Ref: Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors. PMID: 19014680 |
Ref: Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors. PMID: 19492075 |
Ref: Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells. PMID: 21447798 Ref: A correction to the research article titled: "Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells" by A. S. Little, K. Balmanno, M. J. Sale, S. Newman, J. R. Dry, M. Hampson, P PMID: 21674991 |
Ref: miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes. PMID: 21557394 Ref: Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212. PMID: 22169769 |
Ref: Acute tumour response to the MEK1/2 inhibitor selumetinib (AZD6244, ARRY-142886) evaluated by non-invasive diffusion-weighted MRI. PMID: 23942066 Ref: Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models. PMID: 24045180 |
Ref: Trametinib. PMID: 24756797 |
Ref: Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. PMID: 27028006 |
Ref: Identification of key genes in colorectal cancer using random walk with restart. PMID: 28000901 Ref: A food-based approach that targets interleukin-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis. PMID: 28193578 |
Ref: Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1. PMID: 30382763 |