Primary Site >> Pancreatic Cancer
Gene >> CDKN2A
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Ref: Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. PMID: 7726912 |
Ref: CDKN2 explains part of the clinical phenotype in Dutch familial atypical multiple-mole melanoma (FAMMM) syndrome families. PMID: 7640518 Ref: Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations. PMID: 7666916 Ref: Brief report: a familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene. PMID: 7666917 Ref: MTS-1 (CDKN2) tumor suppressor gene deletions are a frequent event in esophagus squamous cancer and pancreatic adenocarcinoma cell lines. PMID: 7845688 Ref: Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas. PMID: 8589035 |
Ref: Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors. PMID: 8613012 Ref: Role of the INK4a locus in tumor suppression and cell mortality. PMID: 8620534 Ref: Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy. PMID: 8640765 Ref: Deletion and mutation analyses of the P16/MTS-1 tumor suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas. PMID: 8640773 Ref: Pancreatic adenocarcinoma: epidemiology and genetics. PMID: 8950667 Ref: Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice. PMID: 8971180 Ref: [Expression of P16 protein in pancreatic carcinoma]. PMID: 9389057 Ref: INK4 genes in pancreatic carcinoma. PMID: 21594446 |
Ref: Advances in molecular genetics. PMID: 9046882 Ref: Tumor-suppressive pathways in pancreatic carcinoma. PMID: 9135016 Ref: p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. PMID: 9187111 Ref: Molecular diagnosis of pancreas carcinoma. PMID: 9219065 Ref: Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. PMID: 9242437 Ref: [Molecular diagnosis of pancreatic cancer]. PMID: 9276865 Ref: Expression of methylthioadenosine phosphorylase cDNA in p16-, MTAP- malignant cells: restoration of methylthioadenosine phosphorylase-dependent salvage pathways and alterations of sensitivity to inhibitors of purine de novo synthesis. PMID: 9351982 Ref: The molecular genetics of pancreatic cancer. PMID: 9364657 Ref: Molecular advances in pancreatic cancer. PMID: 9438601 Ref: Hereditary pancreatitis and familial pancreatic cancer. PMID: 9438603 Ref: Frequent loss of p16 expression and its correlation with clinicopathological parameters in pancreatic carcinoma. PMID: 9815833 |
Ref: Genetic alterations in gastrinomas and nonfunctioning pancreatic neuroendocrine tumors: an analysis of p16/MTS1 tumor suppressor gene inactivation. PMID: 9443399 Ref: Genetics of pancreatic cancer. From genes to families. PMID: 9443984 Ref: Aberrant p16INK4 expression related to clinical stage and prognosis in patients with pancreatic cancer. PMID: 9538137 Ref: The risk of subsequent primary carcinoma of the pancreas in patients with cutaneous malignant melanoma. PMID: 9576287 Ref: Excess cancer mortality in six Dutch pedigrees with the familial atypical multiple mole-melanoma syndrome from 1830 to 1994. PMID: 9579547 Ref: Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. PMID: 9622070 Ref: Molecular pattern of ductal pancreatic cancer. PMID: 9641882 Ref: Comparative phenotypic studies of duct epithelial cell lines derived from normal human pancreas and pancreatic carcinoma. PMID: 9665487 Ref: Mutational analysis of the P16-binding domain of cyclin-dependent kinase 4 in tumors in the head region of the pancreas. PMID: 9667525 Ref: Accumulation of genetic alterations and their significance in each primary human cancer and cell line. PMID: 9685701 Ref: Recent discoveries in cancer genetics of exocrine pancreatic neoplasia. PMID: 9705534 Ref: Alteration of the CDKN2A gene in pancreatic cancers: Is it a late event in the progression of pancreatic cancer? PMID: 9735394 Ref: Gene therapy and pancreatic cancer. PMID: 9792901 Ref: The molecular and cellular biology of pancreatic cancer. PMID: 9807701 Ref: A novel strategy for inhibiting growth of human pancreatic cancer cells by blocking cyclin-dependent kinase activity. PMID: 9841966 Ref: Novel germline p16(INK4) allele (Asp145Cys) in a family with multiple pancreatic carcinomas. Mutations in brief no. 148. Online. PMID: 10627132 Ref: Five novel somatic CDKN2/p16 mutations identified in melanoma, glioma and carcinoma of the pancreas. Mutations in brief no. 170. Online. PMID: 10651484 |
Ref: TGFbeta-induced growth inhibition involves cell cycle inhibitor p21 and pRb independent from p15 expression. PMID: 9863014 Ref: Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas. PMID: 10027410 Ref: Impact of p16 expression on surgical management of malignant melanoma and pancreatic carcinoma. PMID: 10037301 Ref: Characterization of six cell lines established from human pancreatic adenocarcinomas. PMID: 10091760 Ref: Immunohistochemical and molecular analysis of giant cell carcinoma of the pancreas: a report of three cases. PMID: 10206490 Ref: Role of p53 and p16 gene alterations in determining response to concurrent paclitaxel and radiation in solid tumor. PMID: 10210535 Ref: Malignant fibrous histiocytoma of the pancreas: a case report with genetic analysis. PMID: 10357405 Ref: Prognosis of human pancreatic adenocarcinoma: review of clinical and histopathological variables and possible uses of new molecular methods. PMID: 10365829 Ref: Molecular pathology of invasive carcinoma. PMID: 10415852 Ref: Orthotopic models of human pancreatic cancer. PMID: 10415855 Ref: Progress in cancer genetics: lessons from pancreatic cancer. PMID: 10436774 Ref: Pathology of incipient pancreatic cancer. PMID: 10436775 Ref: Familial pancreatic cancer. PMID: 10436789 Ref: Biliopancreatic malignancy: screening the at risk patient with molecular markers. PMID: 10436811 Ref: The future of surgery for pancreatic cancer. PMID: 10436842 Ref: Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus. PMID: 10445844 Ref: Genetic background determines the response to adenovirus-mediated wild-type p53 expression in pancreatic tumor cells. PMID: 10505853 Ref: Characterization of ligurian melanoma families and risk of occurrence of other neoplasia. PMID: 10508477 Ref: The genetics of hereditary melanoma and nevi. 1998 update. PMID: 10630172 Ref: P16INK4a expression adenovirus vector to suppress pancreas cancer cell proliferation. PMID: 10632358 Ref: Molecular genetics and related developments in pancreatic cancer. PMID: 17023981 |
Ref: Molecular biology of pancreatic cancer; oncogenes, tumour suppressor genes, growth factors, and their receptors from a clinical perspective. PMID: 10660490 Ref: Inherited predisposition to pancreatic adenocarcinoma: role of family history and germ-line p16, BRCA1, and BRCA2 mutations. PMID: 10667595 Ref: Germline CDKN2A mutation implicated in predisposition to multiple myeloma. PMID: 10688850 Ref: Patients with both pancreatic adenocarcinoma and melanoma may harbor germline CDKN2A mutations. PMID: 10719365 Ref: [General rules for the study of pancreatic cancer by molecular biological aspect]. PMID: 10734643 Ref: Hypermethylation of multiple genes in pancreatic adenocarcinoma. PMID: 10766168 Ref: Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent. PMID: 10781373 Ref: Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations. PMID: 10861313 Ref: Molecular analysis of microdissected tumors and preneoplastic intraductal lesions in pancreatic carcinoma. PMID: 10880379 Ref: High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families. PMID: 10922411 Ref: Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of four commercial antibodies. PMID: 10937052 Ref: Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma. PMID: 10950061 Ref: Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 (p16-Leiden). PMID: 10956390 Ref: Inhibition of pRb phosphorylation and cell cycle progression by an antennapedia-p16(INK4A) fusion peptide in pancreatic cancer cells. PMID: 10996726 Ref: A novel germline mutation, P48T, in the CDKN2A/p16 gene in a patient with pancreatic carcinoma. PMID: 11058911 Ref: Multiple primary tumors as an indicator for p16INK4a germline mutations in pancreatic cancer patients? PMID: 11075991 Ref: [Study on the relationship of alteration and expression of p16 gene to pancreatic carcinoma]. PMID: 11110976 Ref: Genetic counseling and testing for germline p16 mutations in two pancreatic cancer-prone families. PMID: 11113097 Ref: The physiology of p16(INK4A)-mediated G1 proliferative arrest. PMID: 11325039 Ref: [The growth inhibitory effects by transfection of p16 gene on human pancreatic cancer cell line]. PMID: 11832084 Ref: [Alterations of the p16 gene for the carcinogenesis in pancreas]. PMID: 12903437 Ref: Molecular genetics of ductal pancreatic neoplasia. PMID: 17031113 |
Ref: Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines. PMID: 11115575 Ref: A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. PMID: 11159909 Ref: Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. PMID: 11161385 Ref: Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping. PMID: 11169959 Ref: Successful xenografting of cryopreserved primary pancreatic cancers. PMID: 11253117 Ref: Update on familial pancreatic cancer. PMID: 11276379 Ref: p16(INK4a) alterations in chronic pancreatitis-indicator for high-risk lesions for pancreatic cancer. PMID: 11283541 Ref: The role of genetic factors in the etiology of pancreatic adenocarcinoma: an update. PMID: 11291558 Ref: Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo. PMID: 11313791 Ref: Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms. PMID: 11382316 Ref: Prevention of pancreatic cancer and strategies for management of familial pancreatic cancer. PMID: 11385254 Ref: Tumor suppressor genes in the 9p21 gene cluster are selective targets of inactivation in neuroendocrine gastroenteropancreatic tumors. PMID: 11479232 Ref: Molecular diagnosis of pancreatic cancer. PMID: 11490843 Ref: Molecular biology of pancreatic cancer: potential clinical implications. PMID: 11520255 Ref: Molecular pathology of pancreatic cancer. PMID: 11561601 Ref: Adenovirus-mediated wt-p16 reintroduction induces cell cycle arrest or apoptosis in pancreatic cancer. PMID: 11687897 Ref: Immunohistochemical [corrected] detection of the alternate INK4a-encoded tumor suppressor protein p14(ARF) in archival human cancers and cell lines using commercial antibodies: correlation with p16(INK4a) expression. PMID: 11706079 Ref: Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16(INK4a) and p15(INK4b) cDNAs and their homozygous gene deletion in cheek pouch and pancreatic tumor cells. PMID: 11707341 Ref: Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. PMID: 11787853 Ref: TGF alpha transgenic mice. A model of pancreatic cancer development. PMID: 12120215 Ref: Hereditary pancreatic cancer. PMID: 12120226 Ref: Update of familial pancreatic cancer in Germany. PMID: 12120230 Ref: Pancreatic cancer genetics. PMID: 12120238 Ref: An Epidemiological Overview of Environmental and Genetic Risk Factors of Pancreatic Cancer. PMID: 12718618 Ref: Genetic Testing in Familial Melanoma : Epidemiologic/Genetic Assessment of Risks and Role of CDKN2A Analysis. PMID: 22323255 |
Ref: p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb. PMID: 11753042 Ref: Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia. PMID: 11756558 Ref: Overexpression of pRB in human pancreatic carcinoma cells: function in chemotherapy-induced apoptosis. PMID: 11792751 Ref: High prevalence of the G101W germline mutation in the CDKN2A (P16(ink4a)) gene in 62 Italian malignant melanoma families. PMID: 11807902 Ref: Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome. PMID: 11815963 Ref: Trojan p16 peptide suppresses pancreatic cancer growth and prolongs survival in mice. PMID: 11948142 Ref: Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): additional evidence for a recently proposed model of progression. PMID: 11950919 Ref: Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma. PMID: 12000709 Ref: Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma. PMID: 12010891 Ref: Molecular prognostic markers in pancreatic cancer. PMID: 12021893 Ref: Hereditary factors in pancreatic cancer. PMID: 12021894 Ref: Establishment and characterization of four human pancreatic carcinoma cell lines. Genetic alterations in the TGFBR2 gene but not in the MADH4 gene. PMID: 12037578 Ref: Molecular pathogenesis of pancreatic cancer. PMID: 12063826 Ref: Genetic basis of pancreatic cancer. PMID: 12079267 Ref: [Genetics of pancreatic cancer: recent advances in molecular diagnosis]. PMID: 12094699 Ref: German national case collection of familial pancreatic cancer - clinical-genetic analysis of the first 21 families. PMID: 12119461 Ref: Frequent deletions of tumor suppressor genes in pure pancreatic juice from patients with tumoral or nontumoral pancreatic diseases. PMID: 12120000 Ref: DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma. PMID: 12454109 Ref: CDKN2A germline mutations in familial pancreatic cancer. PMID: 12454511 Ref: The CDKN2A tumour suppressor gene: no mutations detected in patients with melanoma and additional unrelated cancers. PMID: 12459645 Ref: [Expression of DPC4/Smad4, p21wafI, and p16 in human pancreatic cancer]. PMID: 12479060 Ref: [Molecular pathways of pancreatic carcinogenesis]. PMID: 12483152 Ref: Pancreatic cancer: epidemiology, genetics, and approaches to screening. PMID: 12520639 Ref: Minute invasive ductal carcinoma of the residual pancreas after distal pancreatectomy for intraductal papillary-mucinous tumor. PMID: 12622431 |
Ref: Differential roles of alterations of p53, p16, and SMAD4 expression in the progression of intraductal papillary-mucinous tumors of the pancreas. PMID: 12469138 Ref: Tumor-suppressing pathways in cystic pancreatic tumors. PMID: 12499916 Ref: Genetic abnormalities in pancreatic cancer. PMID: 12537585 Ref: Genetic alterations in pancreatic carcinoma. PMID: 12605716 Ref: Methylation status of p14ARF and p16INK4a as detected in pancreatic secretions. PMID: 12610506 Ref: [Pancreatic carcinogenesis. Clinical implications]. PMID: 12647072 Ref: A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform. PMID: 12692724 Ref: Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4A. PMID: 12711305 Ref: The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice. PMID: 12727809 Ref: P53 mutation but not p16/MTS1 mutation occurs in intraductal papillary mucinous tumors of the pancreas. PMID: 12749268 Ref: Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma. PMID: 12802288 Ref: Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. PMID: 12837831 Ref: [The relationship between tumor suppressor genes p14ARF and p53 expression and biological behavior of pancreatic carcinoma]. PMID: 12895341 Ref: Abnormalities of tumor suppressor gene p16 in pancreatic carcinoma: immunohistochemical and genetic findings compared with clinicopathological parameters. PMID: 12898359 Ref: Characterization of the neoplastic phenotype in the familial atypical multiple-mole melanoma-pancreatic carcinoma syndrome. PMID: 12910525 Ref: Laser microdissection of small tissue samples--application to chronic pancreatitis tissues. PMID: 12924436 Ref: Pancreatic carcinoma surveillance in patients with familial melanoma. PMID: 12925390 Ref: p14ARF upregulation of p53 and enhanced effects of 5-fluorouracil in pancreatic cancer. PMID: 12935400 Ref: The genetics of pancreatic cancer. PMID: 12946833 Ref: Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. PMID: 13679454 Ref: Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms. PMID: 14501508 Ref: [Genetic counseling and DNA testing in patients with increased risks for malignant melanoma]. PMID: 14502854 Ref: Pancreatic carcinoma in carriers of a specific 19 base pair deletion of CDKN2A/p16 (p16-leiden). PMID: 14506146 Ref: Pattern of secondary genomic changes in pancreatic tumors of Tgf alpha/Trp53+/- transgenic mice. PMID: 14506698 Ref: Somatostatin receptor gene transfer inhibits established pancreatic cancer xenografts. PMID: 14572771 Ref: Familial sarcoma: challenging pedigrees. PMID: 14584079 Ref: p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis. PMID: 14657708 Ref: Proteomic analysis of pancreatic ductal carcinoma cells treated with 5-aza-2'-deoxycytidine. PMID: 14679576 Ref: The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. PMID: 14681205 Ref: Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. PMID: 14681207 Ref: Surveillance for familial pancreatic cancer. PMID: 14743890 |
Ref: Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors. PMID: 14604895 Ref: INK4/ARF germline alterations in pancreatic cancer patients. PMID: 14679123 Ref: Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma. PMID: 14735200 Ref: [Biallelic inactivation of the p16-Gen in a metachronous triple carcinoma in the oropharyngeal region]. PMID: 14740307 Ref: FAMMM syndrome: pathogenesis and management. PMID: 14871223 Ref: Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity? PMID: 15014986 Ref: Allelotype of ampulla of Vater cancer: highly frequent involvement of chromosome 11. PMID: 15024645 Ref: [Recent advances in gene change of pancreatic cancer]. PMID: 15052782 Ref: Characterization of FAMPAC, a newly identified human pancreatic carcinoma cell line with a hereditary background. PMID: 15112280 Ref: [Expression of proteins in p53 (p14ARF-mdm2-p53-p21WAF/CIP1) pathway and their significance in exocrine pancreatic carcinoma]. PMID: 15132849 Ref: 5-Fluorouracil or gemcitabine combined with adenoviral-mediated reintroduction of p16INK4A greatly enhanced cytotoxicity in Panc-1 pancreatic adenocarcinoma cells. PMID: 15133762 Ref: Familial melanoma, pancreatic cancer and germline CDKN2A mutations. PMID: 15146471 Ref: [Alteration of the K-ras and p16/CDKN2 gene in endocrine pancreatic carcinomas]. PMID: 15148814 Ref: Prospective risk of cancer in CDKN2A germline mutation carriers. PMID: 15173226 Ref: Inherited predisposition to cancer: a historical overview. PMID: 15264268 Ref: The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity. PMID: 15309028 Ref: Restoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes. PMID: 15336553 Ref: Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. PMID: 15367885 Ref: Overexpression of G1-S cyclins and cyclin-dependent kinases during multistage human pancreatic duct cell carcinogenesis. PMID: 15475449 Ref: Familial pancreatic carcinoma in Jews. PMID: 15516847 Ref: Expression profiles of a human pancreatic cancer cell line upon induction of apoptosis search for modulators in cancer therapy. PMID: 15557790 Ref: Molecular analysis of pancreatic juice: a helpful tool to differentiate benign and malignant pancreatic tumors? PMID: 15753605 |
Ref: Survival after surgical management of pancreatic adenocarcinoma: does curative and radical surgery truly exist? PMID: 15578211 Ref: Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway. PMID: 15637593 Ref: Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy. PMID: 15662124 Ref: Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion. PMID: 15688169 Ref: Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas. PMID: 15781639 Ref: MUC1 overexpression is the most reliable marker of invasive carcinoma in intraductal papillary-mucinous tumor (IPMT). PMID: 15816444 Ref: Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas. PMID: 15832194 Ref: Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous deletion in a noninvasive precursor lesion. PMID: 15832197 Ref: AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells. PMID: 15860351 Ref: [Anti-tumor effect of pcDNA3. 1-Egr. 1p-p16 gene combined with radiotherapy in tumor-bearing nude mice]. PMID: 15871178 Ref: The genetics of susceptibility to cutaneous melanoma. PMID: 15883616 Ref: Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines. PMID: 15929091 Ref: Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups. PMID: 15940643 Ref: [Chronic pancreatitis--pancreas cancer: influence of genetic factors]. PMID: 15957615 Ref: In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis. PMID: 15958547 Ref: Cloning of the hamster p16 gene 5' upstream region and its aberrant methylation patterns in pancreatic cancer. PMID: 15979573 Ref: Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma. PMID: 15985168 Ref: Genome-wide aberrations in pancreatic adenocarcinoma. PMID: 16080956 Ref: Identification of oligodendroglioma specific chromosomal copy number changes in the glioblastoma MI-4 cell line by array-CGH and FISH analyses. PMID: 16102584 Ref: Clinical significance of p16 protein expression loss and aberrant p53 protein expression in pancreatic cancer. PMID: 16127777 Ref: Molecular prognostic markers in pancreatic cancer: a systematic review. PMID: 16146690 Ref: Treatment of familial pancreatic cancer and its precursors. PMID: 16162302 Ref: Ductal neoplasia of the pancreas: nosologic, clinicopathologic, and biologic aspects. PMID: 16183479 Ref: [Mucinous noncystic (colloid) adenocarcinoma of the pancreas]. PMID: 16251039 |
Ref: Molecular mechanisms of pancreatic carcinogenesis. PMID: 16367914 Ref: Population-based prevalence of CDKN2A mutations in Utah melanoma families. PMID: 16397522 Ref: DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease. PMID: 16424060 Ref: Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarray. PMID: 16481301 Ref: Molecular pathogenesis of pancreatic cancer. PMID: 16549325 Ref: Gene therapy developments for pancreatic cancer. PMID: 16549328 Ref: Familial pancreatic cancer syndromes. PMID: 16632103 Ref: [Detection of expression of p53, p16, and cyclooxygenase 2 in pancreatic cancer by tissue microarray and correlation among these three genes]. PMID: 16759529 Ref: Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer. PMID: 16818496 Ref: Characterization of pancreatic lesions from MT-tgf alpha, Ela-myc and MT-tgf alpha/Ela-myc single and double transgenic mice. PMID: 16822304 Ref: Immunohistochemical expression of 14-3-3 sigma protein in intraductal papillary-mucinous tumor and invasive ductal carcinoma of the pancreas. PMID: 16886641 Ref: [Familial pancreatic cancer]. PMID: 16888680 Ref: Impact of E27X, a novel CDKN2A germ line mutation, on p16 and p14ARF expression in Italian melanoma families displaying pancreatic cancer and neuroblastoma. PMID: 16893909 Ref: Molecular pathogenesis of pancreatic adenocarcinoma: potential clinical implications. PMID: 16940943 Ref: Physical and functional interaction of the p14ARF tumor suppressor with ribosomes. PMID: 17035234 Ref: High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL. PMID: 17047042 Ref: Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: heteroduplex analysis of limiting dilution PCRs. PMID: 17106238 Ref: [Pancreatic cancer]. PMID: 17111879 Ref: Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. PMID: 17114584 |
Ref: Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents. PMID: 16905682 Ref: K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking. PMID: 17198183 Ref: Different patterns of p16INK4A and p53 protein expressions in intraductal papillary-mucinous neoplasms and pancreatic intraepithelial neoplasia. PMID: 17198188 Ref: Analysis of molecular pathways in sporadic neuroendocrine tumors of the gastro-entero-pancreatic system. PMID: 17278096 Ref: Linkage analysis of chromosome 4 in families with familial pancreatic cancer. PMID: 17312386 Ref: Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. PMID: 17349581 Ref: Long-term survival after radical resection for pancreatic head and ampullary cancer: a potential role for the EGF-R. PMID: 17369680 Ref: Hereditary cancer syndrome diagnosis: molecular genetic clues and cancer control. PMID: 17381417 Ref: Differential expressions of cyclin D1 associated with better prognosis of cancers of ampulla of Vater. PMID: 17420962 Ref: Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians. PMID: 17505013 Ref: Mucinous cystic neoplasms of the pancreas: pathology and molecular genetics. PMID: 17520198 Ref: Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells. PMID: 17535296 Ref: Overexpression of ErbB2 in the exocrine pancreas induces an inflammatory response but not increased proliferation. PMID: 17546589 Ref: Shh signaling and pancreatic cancer: implications for therapy? PMID: 17611415 Ref: p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism. PMID: 17630509 Ref: Solid pseudopapillary neoplasms of the pancreas show an interruption of the Wnt-signaling pathway and express gene products of 11q. PMID: 17632456 Ref: Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer. PMID: 17659731 Ref: Pancreatic intraepithelial neoplasia in heterotopic pancreas: evidence for the progression model of pancreatic ductal adenocarcinoma. PMID: 17667542 Ref: Molecular pathogenesis of pancreatic cancer: advances and challenges. PMID: 17691965 Ref: Construction of targeted plasmid vector pcDNA3.1-Egr.1p-p16 and its expression in pancreatic cancer JF305 cells induced by radiation in vitro. PMID: 17696250 Ref: Identification of methylation-associated gene expression in neuroendocrine pancreatic tumor cells. PMID: 17703082 Ref: [Effect of irradiation-induced pcDNA3.1-Egr.1p-p16 on cell apoptosis and cell cycle of JF305 cells]. PMID: 17715021 Ref: Molecular prognostic factors in patients with pancreatic cancer. PMID: 18020978 Ref: Predicting the risk of pancreatic cancer: on CDKN2A mutations in the melanoma-pancreatic cancer syndrome in Italy. PMID: 18024887 Ref: Aberrant overexpression of an epithelial marker, 14-3-3sigma, in a subset of hematological malignancies. PMID: 18036248 Ref: Genetics: what advice for patients who present with a family history of melanoma? PMID: 18083368 Ref: Familial pancreatic cancer: from genes to improved patient care. PMID: 19072437 |
Ref: Clinical and molecular characterization of patients at risk for hereditary melanoma in southern Brazil. PMID: 17713569 Ref: Pancreatic cancer and the FAMMM syndrome. PMID: 17992582 Ref: Pancreatic cancer. PMID: 18039136 Ref: CDKN2A mutations and melanoma risk in the Icelandic population. PMID: 18178632 Ref: Molecular markers of pancreatic cancer: development and clinical relevance. PMID: 18266003 Ref: Uncommon association of germline mutations of RET proto-oncogene and CDKN2A gene. PMID: 18299477 Ref: Trp53 deletion stimulates the formation of metastatic pancreatic tumors. PMID: 18310506 Ref: Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. PMID: 18332107 Ref: Characterization of K-ras gene mutations in association with mucinous hypersecretion in intraductal papillary-mucinous neoplasms. PMID: 18392710 Ref: Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. PMID: 18515410 Ref: [New molecular targets in pancreatic cancer]. PMID: 18541514 Ref: Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors. PMID: 18547613 Ref: Inducible re-expression of p16 in an orthotopic mouse model of pancreatic cancer inhibits lymphangiogenesis and lymphatic metastasis. PMID: 18577984 Ref: Genetic testing in familial melanoma: uptake and implications. PMID: 18613292 Ref: Pancreatic cancer: a plea for good and comprehensive morphological studies. PMID: 18617774 Ref: Familial melanoma. PMID: 18672145 Ref: Screening and surveillance approaches in familial pancreatic cancer. PMID: 18674702 Ref: Establishment and molecular profiling of a novel human pancreatic cancer panel for 5-FU. PMID: 18691340 Ref: Molecular aspects of carcinogenesis in pancreatic cancer. PMID: 18693168 Ref: Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland. PMID: 18714178 Ref: Undifferentiated carcinoma with osteoclastic giant cells (UCOCGC) of the pancreas associated with the familial atypical multiple mole melanoma syndrome (FAMMM). PMID: 18813118 Ref: International registries of families at high risk of pancreatic cancer. PMID: 18818508 Ref: Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells. PMID: 18949401 Ref: Increased risk of cancer other than melanoma in CDKN2A founder mutation (p16-Leiden)-positive melanoma families. PMID: 18981015 Ref: [Activation of multiple tumor suppressor genes by MBD1 siRNA in pancreatic cancer cell line BxPC-3]. PMID: 19062732 Ref: Is there any relationship between BRCA1 gene mutation and pancreatic cancer development? PMID: 19140568 Ref: Precursor lesions of pancreatic cancer. PMID: 20485640 |
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