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HBV Target gene Detail Information

> ZNF586 Gene Search Result


Gene Information
Gene Name ZNF586
Gene ID 54807
Gene Full Name zinc finger protein 586
Transcripts ENSG00000083828
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoli fibrillar center;Vesicles;
HPA Protein Class Info Predicted intracellular proteins, Transcription factors
Uniport_ID Q9NXT0
HGNC ID HGNC:25949
VEGA ID OTTHUMG00000183477
String ID 9606.ENSP00000379458
PharmGKB ID PA134946358
Target gene [ZNF586] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1010588 chr19 11 11 View
1010910 chr19 10 10 View
1403918 chr19 10 10 View
1403919 chr19 11 11 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of ZNF586 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
ZNF586 expression: Low -> High
Lollipop of ZNF586 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of ZNF586 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of ZNF586 expression and immune infiltrating cell level correlation result in HBV+ samples
ZNF586 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).