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HPV Target gene Detail Information

> ZNF519 Gene Search Result


Gene Information
Gene Name ZNF519
Gene ID 162655
Gene Full Name zinc finger protein 519
Gene Alias HsT2362
Transcripts ENSG00000175322
Virus HPV
Gene Type protein coding
HPA Location Info Nucleoli;
HPA Protein Class Info Predicted intracellular proteins, Transcription factors
Uniport_ID Q8TB69
HGNC ID HGNC:30574
VEGA ID OTTHUMG00000182055
String ID 9606.ENSP00000464872
PharmGKB ID PA134863605
Target gene [ZNF519] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5002130 chr18 13 2 15 View
5403789 chr18 49 11 60 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of ZNF519 expression and immune infiltrating cell level correlation result in HPV+ samples
ZNF519 expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of ZNF519 expression and immune infiltrating cell level correlation result in HPV+ samples
ZNF519 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of ZNF519 expression and immune infiltrating cell level correlation result in HPV+ samples
ZNF519 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of ZNF519 expression and immune infiltrating cell level correlation result in HPV+ samples
ZNF519 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of ZNF519 expression and immune infiltrating cell level correlation result in HPV+ samples
ZNF519 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of ZNF519 expression and immune infiltrating cell level correlation result in HPV+ samples
ZNF519 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of ZNF519 expression and immune infiltrating cell level correlation result in HPV+ samples
ZNF519 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of ZNF519 expression and immune infiltrating cell level correlation result in HPV+ samples
ZNF519 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).