HBV Target gene Detail Information

> ZNF516 Gene Search Result

Gene Information

Gene Name	ZNF516
Gene ID	9658
Gene Full Name	zinc finger protein 516
Gene Alias	HsT287
Transcripts	ENSG00000101493
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Predicted intracellular proteins, Transcription factors
Uniport_ID	Q92618
HGNC ID	HGNC:28990
VEGA ID	OTTHUMG00000165995
OMIM ID	615114
String ID	9606.ENSP00000394757
PharmGKB ID	PA134992707

Target gene [ZNF516] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1004011	chr18	69	18	10	97	View
1004012	chr18	69	18	10	97	View
1004013	chr18	69	18	10	97	View
1004014	chr18	69	18	10	97	View
1004017	chr18	69	18	10	97	View
1004071	chr18	69	16	10	95	View
1017293	chr18	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of ZNF516 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
ZNF516 expression: Low -> High
Lollipop of ZNF516 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of ZNF516 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of ZNF516 expression and immune infiltrating cell level correlation result in HBV+ samples
ZNF516 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).