HIV Target gene Detail Information

> ZMPSTE24 Gene Search Result

Gene Information

Gene Name	ZMPSTE24
Gene ID	10269
Gene Full Name	zinc metallopeptidase STE24
Gene Alias	HGPS; PRO1; FACE1; STE24; FACE-1; Ste24p
Transcripts	ENSG00000084073
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins, Transporters
Uniport_ID	O75844
HGNC ID	HGNC:12877
VEGA ID	OTTHUMG00000005762
OMIM ID	606480
String ID	9606.ENSP00000361845
PharmGKB ID	PA37466
FDA Approved Drug	Lonafarnib

Target gene [ZMPSTE24] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000246	chr1	33	271	347	651	View
4003745	chr1	19	22	14	55	View
4010913	chr1	4	4		8	View
4014259	chr1	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ZMPSTE24 expression and immune infiltrating cell level correlation result in HIV+ samples
ZMPSTE24 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ZMPSTE24 expression and immune infiltrating cell level correlation result in HIV+ samples
ZMPSTE24 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).