HTLV1 Target gene Detail Information

> ZBTB45 Gene Search Result

Gene Information

Gene Name	ZBTB45
Gene ID	84878
Gene Full Name	zinc finger and BTB domain containing 45
Gene Alias	ZNF499
Transcripts	ENSG00000119574
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Nuclear bodies;
HPA Protein Class Info	Predicted intracellular proteins, Transcription factors
Uniport_ID	Q96K62
HGNC ID	HGNC:23715
VEGA ID	OTTHUMG00000183545
String ID	9606.ENSP00000469089
PharmGKB ID	PA162409464

Target gene [ZBTB45] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6024657	chr19	2	1		3	View
6027899	chr19		1		1	View
6027941	chr19		1		1	View
6027974	chr19		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ZBTB45 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ZBTB45 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ZBTB45 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ZBTB45 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).