HBV Target gene Detail Information

> ZAP70 Gene Search Result


Gene Information
Gene Name ZAP70
Gene ID 7535
Gene Full Name zeta chain of T cell receptor associated protein kinase 70
Gene Alias SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70
Transcripts ENSG00000115085
Virus HBV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID P43403
HGNC ID HGNC:12858
VEGA ID OTTHUMG00000153060
OMIM ID 176947
String ID 9606.ENSP00000264972
Drugbank ID BE0001312
PharmGKB ID PA37447
Target gene [ZAP70] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1012493 chr2 5 1 6 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of ZAP70 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
ZAP70 expression: Low -> High
Lollipop of ZAP70 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of ZAP70 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of ZAP70 expression and immune infiltrating cell level correlation result in HBV+ samples
ZAP70 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).