HIV Target gene Detail Information

> YWHAZ Gene Search Result

Gene Information

Gene Name	YWHAZ
Gene ID	7534
Gene Full Name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Gene Alias	HEL4; YWHAD; KCIP-1; HEL-S-3; HEL-S-93; 14-3-3-zeta
Transcripts	ENSG00000164924
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoli rim;Nucleoplasm;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Transporters
Gene Function	Oncogene
Uniport_ID	P63104
HGNC ID	HGNC:12855
VEGA ID	OTTHUMG00000134291
OMIM ID	601288
String ID	9606.ENSP00000379287
Drugbank ID	BE0001174
PharmGKB ID	PA37444

Target gene [YWHAZ] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004682	chr8	31	10		41	View
4004940	chr8	34	3		37	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of YWHAZ expression and immune infiltrating cell level correlation result in HIV+ samples
YWHAZ expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of YWHAZ expression and immune infiltrating cell level correlation result in HIV+ samples
YWHAZ expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).