HIV Target gene Detail Information

> YWHAB Gene Search Result

Gene Information

Gene Name	YWHAB
Gene ID	7529
Gene Full Name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Gene Alias	HS1; GW128; YWHAA; KCIP-1; HEL-S-1
Transcripts	ENSG00000166913
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoli rim;Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P31946
HGNC ID	HGNC:12849
VEGA ID	OTTHUMG00000032549
OMIM ID	601289
String ID	9606.ENSP00000361930
Drugbank ID	BE0008899
PharmGKB ID	PA37438

Target gene [YWHAB] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000483	chr20	41	169	223	433	View
4003498	chr20	23	13	24	60	View
4007517	chr20	19			19	View
4009249	chr20	6	6		12	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of YWHAB expression and immune infiltrating cell level correlation result in HIV+ samples
YWHAB expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of YWHAB expression and immune infiltrating cell level correlation result in HIV+ samples
YWHAB expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).