HIV Target gene Detail Information

> YTHDF2 Gene Search Result

Gene Information

Gene Name	YTHDF2
Gene ID	51441
Gene Full Name	YTH N6-methyladenosine RNA binding protein 2
Gene Alias	CAHL; HGRG8; NY-REN-2
Transcripts	ENSG00000198492
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Cytoplasmic bodies;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q9Y5A9
HGNC ID	HGNC:31675
VEGA ID	OTTHUMG00000003648
OMIM ID	610640
String ID	9606.ENSP00000362918
PharmGKB ID	PA134964518

Target gene [YTHDF2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004069	chr1	43	7		50	View
4006478	chr1	7	13	4	24	View
4009881	chr1	10			10	View
4011540	chr1	6			6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of YTHDF2 expression and immune infiltrating cell level correlation result in HIV+ samples
YTHDF2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of YTHDF2 expression and immune infiltrating cell level correlation result in HIV+ samples
YTHDF2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).