HIV Target gene Detail Information

> YTHDC2 Gene Search Result

Gene Information

Gene Name	YTHDC2
Gene ID	64848
Gene Full Name	YTH domain containing 2
Gene Alias	CAHL; hYTHDC2
Transcripts	ENSG00000047188
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytoplasmic bodies;Nuclear bodies;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q9H6S0
HGNC ID	HGNC:24721
VEGA ID	OTTHUMG00000128837
OMIM ID	616530
String ID	9606.ENSP00000161863
PharmGKB ID	PA134912676

Target gene [YTHDC2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005411	chr5	23	10		33	View
4005521	chr5	21	3	8	32	View
4008905	chr5	12	1		13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of YTHDC2 expression and immune infiltrating cell level correlation result in HIV+ samples
YTHDC2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of YTHDC2 expression and immune infiltrating cell level correlation result in HIV+ samples
YTHDC2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).