HIV Target gene Detail Information

> YES1 Gene Search Result

Gene Information

Gene Name	YES1
Gene ID	7525
Gene Full Name	YES proto-oncogene 1, Src family tyrosine kinase
Gene Alias	Yes; c-yes; HsT441; P61-YES
Transcripts	ENSG00000176105
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;
HPA Protein Class Info	Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	P07947
HGNC ID	HGNC:12841
VEGA ID	OTTHUMG00000131472
OMIM ID	164880
String ID	9606.ENSP00000462468
Drugbank ID	BE0000840
PharmGKB ID	PA37432

Target gene [YES1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001788	chr18	69	29	34	132	View
4008948	chr18	11	2		13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of YES1 expression and immune infiltrating cell level correlation result in HIV+ samples
YES1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of YES1 expression and immune infiltrating cell level correlation result in HIV+ samples
YES1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).