HIV Target gene Detail Information

> XRCC6 Gene Search Result

Gene Information

Gene Name	XRCC6
Gene ID	2547
Gene Full Name	X-ray repair cross complementing 6
Gene Alias	ML8; KU70; TLAA; CTC75; CTCBF; G22P1
Transcripts	ENSG00000196419
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P12956
HGNC ID	HGNC:4055
VEGA ID	OTTHUMG00000151190
OMIM ID	152690
String ID	9606.ENSP00000352257
PharmGKB ID	PA28467

Target gene [XRCC6] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002264	chr22	102			102	View
4014758	chr22	1	1		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of XRCC6 expression and immune infiltrating cell level correlation result in HIV+ samples
XRCC6 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of XRCC6 expression and immune infiltrating cell level correlation result in HIV+ samples
XRCC6 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).