HIV Target gene Detail Information

> XPO1 Gene Search Result

Gene Information

Gene Name	XPO1
Gene ID	7514
Gene Full Name	exportin 1
Gene Alias	emb; CRM1; exp1
Transcripts	ENSG00000082898
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear membrane;Nucleoplasm;Cytosol;Vesicles;
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transporters
Uniport_ID	O14980
HGNC ID	HGNC:12825
VEGA ID	OTTHUMG00000152316
OMIM ID	602559
String ID	9606.ENSP00000384863
Drugbank ID	BE0009643; BE0009694
PharmGKB ID	PA37418

Target gene [XPO1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000380	chr2	255	57	190	502	View
4002656	chr2	4	73	8	85	View
4011994	chr2	6			6	View
4013470	chr2	2	1		3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of XPO1 expression and immune infiltrating cell level correlation result in HIV+ samples
XPO1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of XPO1 expression and immune infiltrating cell level correlation result in HIV+ samples
XPO1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).