HIV Target gene Detail Information

> XPNPEP3 Gene Search Result

Gene Information

Gene Name	XPNPEP3
Gene ID	63929
Gene Full Name	X-prolyl aminopeptidase 3
Gene Alias	APP3; ICP55; NPHPL1
Transcripts	ENSG00000196236
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;Cytosol;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q9NQH7
HGNC ID	HGNC:28052
VEGA ID	OTTHUMG00000151312
OMIM ID	613553
String ID	9606.ENSP00000349658
PharmGKB ID	PA147357130

Target gene [XPNPEP3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003136	chr22	44		25	69	View
4004353	chr22	39	6		45	View
4007460	chr22	16	1	2	19	View
4009472	chr22	9	2		11	View
4300083	chr22	24	12	7	43	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of XPNPEP3 expression and immune infiltrating cell level correlation result in HIV+ samples
XPNPEP3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of XPNPEP3 expression and immune infiltrating cell level correlation result in HIV+ samples
XPNPEP3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).