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HBV Target gene Detail Information

> XBP1 Gene Search Result


Gene Information
Gene Name XBP1
Gene ID 7494
Gene Full Name X-box binding protein 1
Gene Alias XBP2; TREB5; XBP-1; TREB-5
Transcripts ENSG00000100219
Virus HBV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Uniport_ID P17861
HGNC ID HGNC:12801
VEGA ID OTTHUMG00000151094
OMIM ID 194355
String ID 9606.ENSP00000216037
PharmGKB ID PA37400
Target gene [XBP1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1000144 chr21 551 3039 1836 5426 View
1003153 chr22 159 2 161 View
1403210 chr21 551 3039 1836 5426 View
1404573 chr21 9 5 2 16 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of XBP1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
XBP1 expression: Low -> High
Lollipop of XBP1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of XBP1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of XBP1 expression and immune infiltrating cell level correlation result in HBV+ samples
XBP1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).