HIV Target gene Detail Information

> XAF1 Gene Search Result

Gene Information

Gene Name	XAF1
Gene ID	54739
Gene Full Name	XIAP associated factor 1
Gene Alias	BIRC4BP; XIAPAF1; HSXIAPAF1
Transcripts	ENSG00000132530
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;Nucleoplasm;Rods & Rings;
HPA Protein Class Info	Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q6GPH4
HGNC ID	HGNC:30932
VEGA ID	OTTHUMG00000177908
OMIM ID	606717
String ID	9606.ENSP00000354822
PharmGKB ID	PA162409299

Target gene [XAF1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003291	chr17	8	54	2	64	View
4003292	chr17	8	54	2	64	View
4003294	chr17	8	54	2	64	View
4003295	chr17	8	54	2	64	View
4003296	chr17	8	54	2	64	View
4003297	chr17	8	54	2	64	View
4003298	chr17	8	54	2	64	View
4003531	chr17	8	50	1	59	View
4003895	chr17	49	3		52	View
4004019	chr17	2	47	1	50	View
4007447	chr17	19			19	View
4010118	chr17	9	1		10	View
4016612	chr17				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of XAF1 expression and immune infiltrating cell level correlation result in HIV+ samples
XAF1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of XAF1 expression and immune infiltrating cell level correlation result in HIV+ samples
XAF1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).