HIV Target gene Detail Information

> WDR74 Gene Search Result

Gene Information

Gene Name	WDR74
Gene ID	54663
Gene Full Name	WD repeat domain 74
Gene Alias	Nsa1
Transcripts	ENSG00000133316
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoli;Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q6RFH5
HGNC ID	HGNC:25529
VEGA ID	OTTHUMG00000167695
OMIM ID	617947
String ID	9606.ENSP00000432119
PharmGKB ID	PA142670578

Target gene [WDR74] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002392	chr11	96			96	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of WDR74 expression and immune infiltrating cell level correlation result in HIV+ samples
WDR74 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of WDR74 expression and immune infiltrating cell level correlation result in HIV+ samples
WDR74 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).