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HBV Target gene Detail Information

> WDR5 Gene Search Result


Gene Information
Gene Name WDR5
Gene ID 11091
Gene Full Name WD repeat domain 5
Gene Alias SWD3; BIG-3; CFAP89
Transcripts ENSG00000196363
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Predicted intracellular proteins
Uniport_ID P61964
HGNC ID HGNC:12757
VEGA ID OTTHUMG00000131707
OMIM ID 609012
String ID 9606.ENSP00000351446
PharmGKB ID PA37361
Target gene [WDR5] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1000164 chr9 3180 1379 439 4998 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of WDR5 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
WDR5 expression: Low -> High
Lollipop of WDR5 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of WDR5 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of WDR5 expression and immune infiltrating cell level correlation result in HBV+ samples
WDR5 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).