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HPV Target gene Detail Information

> VTCN1 Gene Search Result


Gene Information
Gene Name VTCN1
Gene ID 79679
Gene Full Name V-set domain containing T cell activation inhibitor 1
Gene Alias B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291
Transcripts ENSG00000134258
Virus HPV
Gene Type protein coding
HPA Location Info Plasma membrane;Cell Junctions;Focal adhesion sites;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID Q7Z7D3
HGNC ID HGNC:28873
VEGA ID OTTHUMG00000012118
OMIM ID 608162
String ID 9606.ENSP00000358470
PharmGKB ID PA142670611
Target gene [VTCN1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5402822 chr1 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of VTCN1 expression and immune infiltrating cell level correlation result in HPV+ samples
VTCN1 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of VTCN1 expression and immune infiltrating cell level correlation result in HPV+ samples
VTCN1 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of VTCN1 expression and immune infiltrating cell level correlation result in HPV+ samples
VTCN1 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of VTCN1 expression and immune infiltrating cell level correlation result in HPV+ samples
VTCN1 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of VTCN1 expression and immune infiltrating cell level correlation result in HPV+ samples
VTCN1 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of VTCN1 expression and immune infiltrating cell level correlation result in HPV+ samples
VTCN1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).