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HBV Target gene Detail Information

> VPS4B Gene Search Result


Gene Information
Gene Name VPS4B
Gene ID 9525
Gene Full Name vacuolar protein sorting 4 homolog B
Gene Alias MIG1; SKD1; SKD1B; VPS4-2
Transcripts ENSG00000119541
Virus HBV
Gene Type protein coding
HPA Location Info Vesicles;Intermediate filaments;
HPA Protein Class Info Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID O75351
HGNC ID HGNC:10895
VEGA ID OTTHUMG00000132790
OMIM ID 609983
String ID 9606.ENSP00000238497
PharmGKB ID PA35795
Target gene [VPS4B] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1007981 chr18 23 23 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of VPS4B expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
VPS4B expression: Low -> High
Lollipop of VPS4B expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of VPS4B expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of VPS4B expression and immune infiltrating cell level correlation result in HBV+ samples
VPS4B expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).