HIV Target gene Detail Information

> VPS45 Gene Search Result

Gene Information

Gene Name	VPS45
Gene ID	11311
Gene Full Name	vacuolar protein sorting 45 homolog
Gene Alias	H1; SCN5; VSP45; VPS45A; VPS45B; VPS54A; VSP45A; H1VPS45
Transcripts	ENSG00000136631
Virus	HIV
Gene Type	protein coding
HPA Location Info	Microtubules;
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q9NRW7
HGNC ID	HGNC:14579
VEGA ID	OTTHUMG00000012511
OMIM ID	610035
String ID	9606.ENSP00000358126
PharmGKB ID	PA37901

Target gene [VPS45] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001390	chr1	157	11	2	170	View
4001927	chr1	91	14	19	124	View
4002864	chr1	58	3	16	77	View
4003857	chr1	26	12	15	53	View
4004116	chr1	41	7	1	49	View
4004669	chr1	30	11		41	View
4004777	chr1	38	1		39	View
4004834	chr1	28	11		39	View
4006017	chr1	15	8	4	27	View
4006320	chr1	25			25	View
4007305	chr1	6	10	4	20	View
4009313	chr1	9	3		12	View
4010152	chr1	9			9	View
4010934	chr1	8			8	View
4012041	chr1	5			5	View
4015206	chr1	1			1	View
4015934	chr1				0	View
4016730	chr1				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of VPS45 expression and immune infiltrating cell level correlation result in HIV+ samples
VPS45 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of VPS45 expression and immune infiltrating cell level correlation result in HIV+ samples
VPS45 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).