HBV Target gene Detail Information

> VHL Gene Search Result

Gene Information

Gene Name	VHL
Gene ID	7428
Gene Full Name	von Hippel-Lindau tumor suppressor
Gene Alias	RCA1; VHL1; pVHL; HRCA1
Transcripts	ENSG00000134086
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	P40337
HGNC ID	HGNC:12687
VEGA ID	OTTHUMG00000128668
OMIM ID	608537
String ID	9606.ENSP00000256474
PharmGKB ID	PA37307

Target gene [VHL] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	25019072	K130M	X		View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of VHL expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
VHL expression: Low -> High
Lollipop of VHL expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of VHL expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of VHL expression and immune infiltrating cell level correlation result in HBV+ samples
VHL expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).