HIV Target gene Detail Information

> VDR Gene Search Result

Gene Information

Gene Name	VDR
Gene ID	7421
Gene Full Name	vitamin D receptor
Gene Alias	NR1I1; PPP1R163
Transcripts	ENSG00000111424
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;Intermediate filaments;
HPA Protein Class Info	Disease related genes, FDA approved drug targets, Nuclear receptors, Predicted intracellular proteins, Transcription factors, Transporters
Gene Function	Suppressor gene
Uniport_ID	P11473
HGNC ID	HGNC:12679
VEGA ID	OTTHUMG00000169890
OMIM ID	601769
String ID	9606.ENSP00000447173
Drugbank ID	BE0000779
PharmGKB ID	PA37301

Target gene [VDR] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4010280	chr12	7	1	1	9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of VDR expression and immune infiltrating cell level correlation result in HIV+ samples
VDR expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of VDR expression and immune infiltrating cell level correlation result in HIV+ samples
VDR expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).