HIV Target gene Detail Information

> VCL Gene Search Result

Gene Information

Gene Name	VCL
Gene ID	7414
Gene Full Name	vinculin
Gene Alias	MV; MVCL; CMD1W; CMH15; HEL114
Transcripts	ENSG00000035403
Virus	HIV
Gene Type	protein coding
HPA Location Info	Focal adhesion sites;
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P18206
HGNC ID	HGNC:12665
VEGA ID	OTTHUMG00000018498
OMIM ID	193065
String ID	9606.ENSP00000211998
PharmGKB ID	PA37288

Target gene [VCL] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000067	chr10	541	599	254	1394	View
4003074	chr10	64	6		70	View
4005659	chr10	23	6	1	30	View
4010940	chr10	7	1		8	View
4100006	chr10	3	11	3	17	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of VCL expression and immune infiltrating cell level correlation result in HIV+ samples
VCL expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of VCL expression and immune infiltrating cell level correlation result in HIV+ samples
VCL expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).