HIV Target gene Detail Information

> VAV1 Gene Search Result

Gene Information

Gene Name	VAV1
Gene ID	7409
Gene Full Name	vav guanine nucleotide exchange factor 1
Gene Alias	VAV
Transcripts	ENSG00000141968
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	P15498
HGNC ID	HGNC:12657
VEGA ID	OTTHUMG00000181965
OMIM ID	164875
String ID	9606.ENSP00000472929
PharmGKB ID	PA37280

Target gene [VAV1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001281	chr19	12	168	3	183	View
4002703	chr19	66	11	6	83	View
4002872	chr19	49	18	10	77	View
4002873	chr19	49	18	10	77	View
4004916	chr19	37	1		38	View
4005315	chr19	32	1	1	34	View
4006374	chr19	23	2		25	View
4007537	chr19	3	16		19	View
4010413	chr19	7	1	1	9	View
4010573	chr19	7	1		8	View
4010715	chr19	5	3		8	View
4012092	chr19	1	4		5	View
4012467	chr19	4	1		5	View
4015074	chr19	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of VAV1 expression and immune infiltrating cell level correlation result in HIV+ samples
VAV1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of VAV1 expression and immune infiltrating cell level correlation result in HIV+ samples
VAV1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).