HIV Target gene Detail Information

> USP8 Gene Search Result

Gene Information

Gene Name	USP8
Gene ID	9101
Gene Full Name	ubiquitin specific peptidase 8
Gene Alias	UBPY; PITA4; SPG59; HumORF8
Transcripts	ENSG00000138592
Virus	HIV
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Cytosol;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P40818
HGNC ID	HGNC:12631
VEGA ID	OTTHUMG00000131645
OMIM ID	603158
String ID	9606.ENSP00000379721
PharmGKB ID	PA37256

Target gene [USP8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004649	chr15	41			41	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of USP8 expression and immune infiltrating cell level correlation result in HIV+ samples
USP8 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of USP8 expression and immune infiltrating cell level correlation result in HIV+ samples
USP8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).