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HBV Target gene Detail Information

> USP53 Gene Search Result


Gene Information
Gene Name USP53
Gene ID 54532
Gene Full Name ubiquitin specific peptidase 53
Transcripts ENSG00000145390
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Plasma membrane;
HPA Protein Class Info Enzymes, Predicted intracellular proteins
Uniport_ID Q70EK8
HGNC ID HGNC:29255
VEGA ID OTTHUMG00000161331
OMIM ID 617431
String ID 9606.ENSP00000409906
PharmGKB ID PA134940368
Target gene [USP53] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1013391 chr4 1 2 2 5 View
1014581 chr4 2 1 3 View
1014582 chr4 2 1 3 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of USP53 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
USP53 expression: Low -> High
Lollipop of USP53 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of USP53 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of USP53 expression and immune infiltrating cell level correlation result in HBV+ samples
USP53 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).