HIV Target gene Detail Information

> USP3 Gene Search Result

Gene Information

Gene Name	USP3
Gene ID	9960
Gene Full Name	ubiquitin specific peptidase 3
Gene Alias	UBP; SIH003
Transcripts	ENSG00000140455
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Midbody ring;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q9Y6I4
HGNC ID	HGNC:12626
VEGA ID	OTTHUMG00000172309
OMIM ID	604728
String ID	9606.ENSP00000369681
PharmGKB ID	PA37251

Target gene [USP3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000078	chr15	225	374	667	1266	View
4000219	chr15	442	106	158	706	View
4001323	chr15	17	56	105	178	View
4001797	chr15	121	7	3	131	View
4004463	chr15	40	4		44	View
4005037	chr15	29	5	2	36	View
4008002	chr15	16		1	17	View
4008601	chr15	8	6		14	View
4009443	chr15	11			11	View
4011049	chr15	4	3		7	View
4012456	chr15		5		5	View
4013160	chr15	1	3		4	View
4013861	chr15	1	2		3	View
4015910	chr15				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of USP3 expression and immune infiltrating cell level correlation result in HIV+ samples
USP3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of USP3 expression and immune infiltrating cell level correlation result in HIV+ samples
USP3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).