HTLV1 Target gene Detail Information

> USP28 Gene Search Result

Gene Information

Gene Name	USP28
Gene ID	57646
Gene Full Name	ubiquitin specific peptidase 28
Transcripts	ENSG00000048028
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Nuclear bodies;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q96RU2
HGNC ID	HGNC:12625
VEGA ID	OTTHUMG00000168205
OMIM ID	610748
String ID	9606.ENSP00000003302
PharmGKB ID	PA37250

Target gene [USP28] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6011534	chr11	21	5		26	View
6020669	chr11	6			6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of USP28 expression and immune infiltrating cell level correlation result in HTLV1+ samples
USP28 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of USP28 expression and immune infiltrating cell level correlation result in HTLV1+ samples
USP28 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of USP28 expression and immune infiltrating cell level correlation result in HTLV1+ samples
USP28 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).