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HTLV1 Target gene Detail Information

> USP22 Gene Search Result


Gene Information
Gene Name USP22
Gene ID 23326
Gene Full Name ubiquitin specific peptidase 22
Gene Alias USP3L
Transcripts ENSG00000124422
Virus HTLV1
Gene Type protein coding
HPA Location Info Nuclear speckles;
HPA Protein Class Info Enzymes, Predicted intracellular proteins
Gene Function Oncogene
Uniport_ID Q9UPT9
HGNC ID HGNC:12621
VEGA ID OTTHUMG00000133621
OMIM ID 612116
String ID 9606.ENSP00000261497
PharmGKB ID PA37247
Target gene [USP22] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6000928 chr6 112 335 255 702 View
6004343 chr17 29 66 24 119 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of USP22 expression and immune infiltrating cell level correlation result in HTLV1+ samples
USP22 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of USP22 expression and immune infiltrating cell level correlation result in HTLV1+ samples
USP22 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of USP22 expression and immune infiltrating cell level correlation result in HTLV1+ samples
USP22 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).