HIV Target gene Detail Information

> UQCRC2 Gene Search Result

Gene Information

Gene Name	UQCRC2
Gene ID	7385
Gene Full Name	ubiquinol-cytochrome c reductase core protein 2
Gene Alias	QCR2; UQCR2; MC3DN5
Transcripts	ENSG00000140740
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P22695
HGNC ID	HGNC:12586
VEGA ID	OTTHUMG00000131585
OMIM ID	191329
String ID	9606.ENSP00000268379
Drugbank ID	BE0003855
PharmGKB ID	PA37217

Target gene [UQCRC2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003285	chr16	63		1	64	View
4007551	chr16	15	4		19	View
4007970	chr16	17			17	View
4010115	chr16	10			10	View
4011012	chr16	6	1		7	View
4012905	chr16	4			4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of UQCRC2 expression and immune infiltrating cell level correlation result in HIV+ samples
UQCRC2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of UQCRC2 expression and immune infiltrating cell level correlation result in HIV+ samples
UQCRC2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).