HTLV1 Target gene Detail Information

> UNC5B Gene Search Result

Gene Information

Gene Name	UNC5B
Gene ID	219699
Gene Full Name	unc-5 netrin receptor B
Gene Alias	UNC5H2; p53RDL1
Transcripts	ENSG00000107731
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Plasma proteins, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	Q8IZJ1
HGNC ID	HGNC:12568
VEGA ID	OTTHUMG00000018422
OMIM ID	607870
String ID	9606.ENSP00000334329
PharmGKB ID	PA37205

Target gene [UNC5B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6006978	chr10	35	10	16	61	View
6015525	chr10	7	6	1	14	View
6019739	chr10	4	3		7	View
6031744	chr10				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of UNC5B expression and immune infiltrating cell level correlation result in HTLV1+ samples
UNC5B expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of UNC5B expression and immune infiltrating cell level correlation result in HTLV1+ samples
UNC5B expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of UNC5B expression and immune infiltrating cell level correlation result in HTLV1+ samples
UNC5B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).