HIV Target gene Detail Information

> UNC13D Gene Search Result

Gene Information

Gene Name	UNC13D
Gene ID	201294
Gene Full Name	unc-13 homolog D
Gene Alias	FHL3; HLH3; HPLH3; Munc13-4
Transcripts	ENSG00000092929
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Vesicles;
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q70J99
HGNC ID	HGNC:23147
VEGA ID	OTTHUMG00000179895
OMIM ID	608897
String ID	9606.ENSP00000207549
PharmGKB ID	PA134919958
FDA Approved Drug	Emapalumab-lzsg

Target gene [UNC13D] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003237	chr17	43	20	1	64	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of UNC13D expression and immune infiltrating cell level correlation result in HIV+ samples
UNC13D expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of UNC13D expression and immune infiltrating cell level correlation result in HIV+ samples
UNC13D expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).