HBV Target gene Detail Information

> UNC13B Gene Search Result

Gene Information

Gene Name	UNC13B
Gene ID	10497
Gene Full Name	unc-13 homolog B
Gene Alias	UNC13; MUNC13; Unc13h2
Transcripts	ENSG00000198722
Virus	HBV
Gene Type	protein coding
HPA Location Info	Vesicles;Golgi apparatus;Intermediate filaments;Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	O14795
HGNC ID	HGNC:12566
VEGA ID	OTTHUMG00000019856
OMIM ID	605836
String ID	9606.ENSP00000367756
Drugbank ID	BE0010284; BE0009926
PharmGKB ID	PA37203

Target gene [UNC13B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1006910	chr9	31		1	32	View
1008238	chr9	19	3		22	View
1008724	chr9	4	12	3	19	View
1008917	chr9	4	11	3	18	View
1013145	chr9	4	1		5	View
1401219	chr9	4	11	3	18	View
1401220	chr9	31		1	32	View
1401221	chr9	4	12	3	19	View
1401222	chr9	4	1		5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of UNC13B expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
UNC13B expression: Low -> High
Lollipop of UNC13B expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of UNC13B expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of UNC13B expression and immune infiltrating cell level correlation result in HBV+ samples
UNC13B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).