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HBV Target gene Detail Information

> ULK2 Gene Search Result


Gene Information
Gene Name ULK2
Gene ID 9706
Gene Full Name unc-51 like autophagy activating kinase 2
Gene Alias ATG1B; Unc51.2
Transcripts ENSG00000083290
Virus HBV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Enzymes, Predicted intracellular proteins
Uniport_ID Q8IYT8
HGNC ID HGNC:13480
VEGA ID OTTHUMG00000059511
OMIM ID 608650
String ID 9606.ENSP00000378914
Drugbank ID BE0009360
Drug (Cytoscape Annotation) Bosutinib;RuxolitinibPhosphate;SunitinibMalate
PharmGKB ID PA37780
Target gene [ULK2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1006292 chr17 40 40 View
1400708 chr17 40 40 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of ULK2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
ULK2 expression: Low -> High
Lollipop of ULK2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of ULK2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of ULK2 expression and immune infiltrating cell level correlation result in HBV+ samples
ULK2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).