HIV Target gene Detail Information

> UBR5 Gene Search Result

Gene Information

Gene Name	UBR5
Gene ID	51366
Gene Full Name	ubiquitin protein ligase E3 component n-recognin 5
Gene Alias	DD5; EDD; HYD; EDD1
Transcripts	ENSG00000104517
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Cancer-related genes, Enzymes, Predicted intracellular proteins
Uniport_ID	O95071
HGNC ID	HGNC:16806
VEGA ID	OTTHUMG00000164755
OMIM ID	608413
String ID	9606.ENSP00000429084
PharmGKB ID	PA162408175

Target gene [UBR5] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002257	chr8	15	75	13	103	View
4007699	chr8	14	4		18	View
4011796	chr8	5	1		6	View
4015460	chr8	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of UBR5 expression and immune infiltrating cell level correlation result in HIV+ samples
UBR5 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of UBR5 expression and immune infiltrating cell level correlation result in HIV+ samples
UBR5 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).