HIV Target gene Detail Information

> UBR3 Gene Search Result

Gene Information

Gene Name	UBR3
Gene ID	130507
Gene Full Name	ubiquitin protein ligase E3 component n-recognin 3
Gene Alias	ZNF650
Transcripts	ENSG00000144357
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoli;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q6ZT12
HGNC ID	HGNC:30467
VEGA ID	OTTHUMG00000132229
OMIM ID	613831
String ID	9606.ENSP00000396068
PharmGKB ID	PA162407919

Target gene [UBR3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003535	chr2	5	54		59	View
4008957	chr2	10	3		13	View
4009560	chr2	2	6	3	11	View
4013663	chr2	3			3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of UBR3 expression and immune infiltrating cell level correlation result in HIV+ samples
UBR3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of UBR3 expression and immune infiltrating cell level correlation result in HIV+ samples
UBR3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).