HBV Target gene Detail Information

> UBE3C Gene Search Result

Gene Information

Gene Name	UBE3C
Gene ID	9690
Gene Full Name	ubiquitin protein ligase E3C
Gene Alias	HECTH2
Transcripts	ENSG00000009335
Virus	HBV
Gene Type	protein coding
HPA Location Info	Mitochondria;Nucleoplasm;Plasma membrane;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	Q15386
HGNC ID	HGNC:16803
VEGA ID	OTTHUMG00000157239
OMIM ID	614454
String ID	9606.ENSP00000309198
PharmGKB ID	PA134905339

Target gene [UBE3C] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1011120	chr7	7	3		10	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of UBE3C expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
UBE3C expression: Low -> High
Lollipop of UBE3C expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of UBE3C expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of UBE3C expression and immune infiltrating cell level correlation result in HBV+ samples
UBE3C expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).