HBV Target gene Detail Information

> UBE3A Gene Search Result

Gene Information

Gene Name	UBE3A
Gene ID	7337
Gene Full Name	ubiquitin protein ligase E3A
Gene Alias	AS; ANCR; E6-AP; HPVE6A; EPVE6AP
Transcripts	ENSG00000114062
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q05086
HGNC ID	HGNC:12496
VEGA ID	OTTHUMG00000171548
OMIM ID	601623
String ID	9606.ENSP00000232165
PharmGKB ID	PA37144

Target gene [UBE3A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1011655	chr15	7	1		8	View
1400935	chr15	7	1		8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of UBE3A expression and immune infiltrating cell level correlation result in HBV+ samples
UBE3A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).