HIV Target gene Detail Information

> UBE2O Gene Search Result

Gene Information

Gene Name	UBE2O
Gene ID	63893
Gene Full Name	ubiquitin conjugating enzyme E2 O
Gene Alias	E2-230K
Transcripts	ENSG00000175931
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Nuclear bodies;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q9C0C9
HGNC ID	HGNC:29554
VEGA ID	OTTHUMG00000180178
OMIM ID	617649
String ID	9606.ENSP00000323687
PharmGKB ID	PA142670651

Target gene [UBE2O] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001620	chr17	129	8	9	146	View
4004141	chr17	15	33		48	View
4005471	chr17	28	4		32	View
4010632	chr17	2	6		8	View
4013102	chr17	1	3		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of UBE2O expression and immune infiltrating cell level correlation result in HIV+ samples
UBE2O expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of UBE2O expression and immune infiltrating cell level correlation result in HIV+ samples
UBE2O expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).