HIV Target gene Detail Information

> UBE2D2 Gene Search Result

Gene Information

Gene Name	UBE2D2
Gene ID	7322
Gene Full Name	ubiquitin conjugating enzyme E2 D2
Gene Alias	UBC4; PUBC1; UBCH4; UBC4/5; UBCH5B; E2(17)KB2
Transcripts	ENSG00000131508
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins, Transporters
Uniport_ID	P62837
HGNC ID	HGNC:12475
VEGA ID	OTTHUMG00000163282
OMIM ID	602962
String ID	9606.ENSP00000381717
Drugbank ID	BE0004530
PharmGKB ID	PA37125

Target gene [UBE2D2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002311	chr5	10	32	58	100	View
4003395	chr5	10	25	27	62	View
4004471	chr5	7	14	23	44	View
4004614	chr5	7	14	21	42	View
4004757	chr5	7	12	21	40	View
4004758	chr5	7	12	21	40	View
4004759	chr5	7	12	21	40	View
4004760	chr5	7	12	21	40	View
4004761	chr5	7	12	21	40	View
4004762	chr5	7	12	21	40	View
4004845	chr5	7	11	21	39	View
4004846	chr5	7	11	21	39	View
4004847	chr5	7	11	21	39	View
4004848	chr5	7	11	21	39	View
4005019	chr5	7	11	19	37	View
4007760	chr5	14		4	18	View
4008973	chr5	13			13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of UBE2D2 expression and immune infiltrating cell level correlation result in HIV+ samples
UBE2D2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of UBE2D2 expression and immune infiltrating cell level correlation result in HIV+ samples
UBE2D2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).