HIV Target gene Detail Information

> UBE2B Gene Search Result

Gene Information

Gene Name	UBE2B
Gene ID	7320
Gene Full Name	ubiquitin conjugating enzyme E2 B
Gene Alias	HR6B; UBC2; HHR6B; RAD6B; E2-17kDa
Transcripts	ENSG00000119048
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Plasma membrane;Cytosol;Vesicles;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	P63146
HGNC ID	HGNC:12473
VEGA ID	OTTHUMG00000129120
OMIM ID	179095
String ID	9606.ENSP00000265339
PharmGKB ID	PA37123

Target gene [UBE2B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000378	chr5	499	4		503	View
4000395	chr5	488	4		492	View
4002723	chr5	68	6	8	82	View
4005921	chr5	27	1		28	View
4005967	chr5	26	1	1	28	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of UBE2B expression and immune infiltrating cell level correlation result in HIV+ samples
UBE2B expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of UBE2B expression and immune infiltrating cell level correlation result in HIV+ samples
UBE2B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).