HIV Target gene Detail Information

> TYK2 Gene Search Result

Gene Information

Gene Name	TYK2
Gene ID	7297
Gene Full Name	tyrosine kinase 2
Gene Alias	JTK1; IMD35
Transcripts	ENSG00000105397
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P29597
HGNC ID	HGNC:12440
VEGA ID	OTTHUMG00000166373
OMIM ID	176941
String ID	9606.ENSP00000431885
Drugbank ID	BE0004146
PharmGKB ID	PA37094

Target gene [TYK2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003208	chr19	66	1		67	View
4012531	chr19	5			5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TYK2 expression and immune infiltrating cell level correlation result in HIV+ samples
TYK2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TYK2 expression and immune infiltrating cell level correlation result in HIV+ samples
TYK2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).