HBV Target gene Detail Information

> TXNRD2 Gene Search Result

Gene Information

Gene Name	TXNRD2
Gene ID	10587
Gene Full Name	thioredoxin reductase 2
Gene Alias	TR; TR3; SELZ; GCCD5; TRXR2; TR-BETA
Transcripts	ENSG00000184470
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Mitochondria;Vesicles;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q9NNW7
HGNC ID	HGNC:18155
VEGA ID	OTTHUMG00000149975
OMIM ID	606448
String ID	9606.ENSP00000383365
Drugbank ID	BE0003388
PharmGKB ID	PA38302

Target gene [TXNRD2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1003530	chr22	52	19	55	126	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of TXNRD2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
TXNRD2 expression: Low -> High
Lollipop of TXNRD2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of TXNRD2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of TXNRD2 expression and immune infiltrating cell level correlation result in HBV+ samples
TXNRD2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).