HPV Target gene Detail Information

> TXN Gene Search Result

Gene Information

Gene Name	TXN
Gene ID	7295
Gene Full Name	thioredoxin
Gene Alias	TRX; TRDX; TRX1
Transcripts	ENSG00000136810
Virus	HPV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	P10599
HGNC ID	HGNC:12435
VEGA ID	OTTHUMG00000020480
OMIM ID	187700
String ID	9606.ENSP00000363641
Drugbank ID	BE0004890; BE0004965
PharmGKB ID	PA37091

Target gene [TXN] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5402022	chr9	53			53	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO)	Head and neck squamous cell carcinoma	134	Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE138080 (GEO)	Cervical intraepithelial neoplasia	25	Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of TXN expression and immune infiltrating cell level correlation result in HPV+ samples
TXN expression: Low -> High

> Dataset: GSE40774
HeatMap of cell type fractions in all samples	Lollipop of TXN expression and immune infiltrating cell level correlation result in HPV+ samples
TXN expression: Low -> High

> Dataset: GSE138080
HeatMap of cell type fractions in all samples	Lollipop of TXN expression and immune infiltrating cell level correlation result in HPV+ samples
TXN expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of TXN expression and immune infiltrating cell level correlation result in HPV+ samples
TXN expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).