HIV Target gene Detail Information

> TXK Gene Search Result

Gene Information

Gene Name	TXK
Gene ID	7294
Gene Full Name	TXK tyrosine kinase
Gene Alias	RLK; TKL; BTKL; PTK4; PSCTK5
Transcripts	ENSG00000074966
Virus	HIV
Gene Type	protein coding
HPA Location Info	Vesicles;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	P42681
HGNC ID	HGNC:12434
VEGA ID	OTTHUMG00000102065
OMIM ID	600058
String ID	9606.ENSP00000264316
Drugbank ID	BE0009357
PharmGKB ID	PA37090

Target gene [TXK] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003281	chr4	43	22		65	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TXK expression and immune infiltrating cell level correlation result in HIV+ samples
TXK expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TXK expression and immune infiltrating cell level correlation result in HIV+ samples
TXK expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).