HTLV1 Target gene Detail Information

> TUBA1B Gene Search Result

Gene Information

Gene Name	TUBA1B
Gene ID	10376
Gene Full Name	tubulin alpha 1b
Gene Alias	K-ALPHA-1
Transcripts	ENSG00000123416
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Microtubules;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	P68363
HGNC ID	HGNC:18809
VEGA ID	OTTHUMG00000170410
OMIM ID	602530
String ID	9606.ENSP00000336799
Drugbank ID	BE0001275
PharmGKB ID	PA162407332

Target gene [TUBA1B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6100121	chr12	235	54	1	290	View
6100122	chr12	202	31		233	View
6100123	chr12	80	48		128	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of TUBA1B expression and immune infiltrating cell level correlation result in HTLV1+ samples
TUBA1B expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of TUBA1B expression and immune infiltrating cell level correlation result in HTLV1+ samples
TUBA1B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).